多种铁剂治疗小儿缺铁性贫血的临床疗效观察  

Observation on the clinical efficacy of various iron agents in the treatment of iron deficiency anemia in children

作　　者：崔怡 CUI Yi(Ganjingzi District Maternal and Child Health Hospital,Dalian 116033,China)

机构地区：[1]大连市甘井子区妇幼保健院,116033

出　　处：《中国现代药物应用》2023年第21期101-103,共3页Chinese Journal of Modern Drug Application

摘　　要：目的 观察小儿缺铁性贫血采用多种铁剂治疗的临床疗效。方法 90例小儿缺铁性贫血患儿,采用抽签法分为A组、B组、C组,每组30例。A组患儿接受蛋白琥珀酸铁治疗, B组患儿接受葡萄糖酸亚铁糖浆治疗, C组患儿接受小儿硫酸亚铁糖浆治疗。对比三组治疗效果,治疗后血红蛋白、血清铁、血清铁蛋白、红细胞平均体积水平,不良反应发生情况。结果 治疗后, A组治疗总有效率为96.67%, B组治疗总有效率为93.33%, C组治疗总有效率为93.33%;三组治疗总有效率两两比较,差异无统计学意义(P>0.05)。治疗后, A组血红蛋白、血清铁、血清铁蛋白、红细胞平均体积分别为(123.98±7.01)g/L、(16.69±4.89)μmol/L、(40.98±9.04)μg/L、(87.01±6.02)fl, B组分别为(112.01±7.02)g/L、(12.07±3.17)μmol/L、(30.99±8.97)μg/L、(78.98±9.01)fl, C组分别为(110.23±7.01)g/L、(9.87±3.17)μmol/L、(30.01±9.98)μg/L、(75.96±7.79)fl;A组血红蛋白、血清铁、血清铁蛋白、红细胞平均体积水平均显著高于B组与C组,差异有统计学意义(P<0.05)。A组的不良反应发生率为3.33%,明显低于B组的23.33%以及C组的30.00%,差异有统计学意义(P<0.05)。B组和C组的不良反应发生率比较差异无统计学意义(P>0.05)。结论 在小儿缺铁性贫血治疗中,多种铁剂在治疗效果上无明显差别,但蛋白琥珀酸铁的不良反应发生率更低,对贫血指标的改善更明显。Objective To observe the clinical efficacy of various iron agents in the treatment of iron deficiency anemia in children.Methods A total of 90 children with iron deficiency anemia were divided into group A,Group B and group C,with 30 cases in each group.Group A was treated with iron protein succinylate,group B was treated with ferrous gluconate syrup,and group C was treated with pediatric ferrous sulfate syrup.The therapeutic effect,levels of hemoglobin,serum iron,serum ferritin and mean corpuscular volume after treatment,and the occurrence of adverse reactions were compared among the three groups.Results After treatment,the total effective rate was 96.67%in group A,93.33%in group B and 93.33%in group C.There was no statistically significant difference in the total effective rate between the three groups(P>0.05).After treatment,the hemoglobin,serum iron,serum ferritin and mean corpuscular volume in group A were(123.98±7.01)g/L,(16.69±4.89)μmol/L,(40.98±9.04)μg/L and(87.01±6.02)fl,those in group B were(112.01±7.02)g/L,(12.07±3.17)μmol/L,(30.99±8.97)μg/L and(78.98±9.01)fl,and those in group C were(110.23±7.01)g/L,(9.87±3.17)μmol/L,(30.01±9.98)μg/L and(75.96±7.79)fl.The levels of hemoglobin,serum iron,serum ferritin and mean corpuscular volume in group A were significantly higher than those in group B and group C,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in group A was 3.33%,which was significantly lower than that of 23.33%in group B and that of 30.00%in group C,and the difference were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between group B and group C(P>0.05).Conclusion There is no significant difference in the effect of various iron agents in the treatment of children with iron deficiency anemia,but the advantage of iron protein succinylate is more obvious.

关 键 词：小儿缺铁性贫血 蛋白琥珀酸铁 葡萄糖酸亚铁 硫酸亚铁 

分 类 号：R725.5[医药卫生—儿科]