甲苯磺酸瑞马唑仑对比丙泊酚用于食管内镜黏膜下剥离术麻醉镇静时血流动力学稳定性研究  

Study on hemodynamic stability of remimazolam tosilate compared with propofol in anesthesia sedation of esophageal endoscopic submucosal dissection

作　　者：徐发明 毛志浩 叶永景 马静宜 郑蓉 郑丽花 XU Faming;MAO Zhihao;YE Yongjing;MA Jingyi;ZHENG Rong;ZHENG Lihua(Department of Anesthesiology,the Second People’s Hospital of Quzhou,Zhejiang,Quzhou 324000,China;Department of Anesthesiology,Quzhou Hospital Affiliated to Wenzhou Medical University,People’s Hospital of Quzhou,Zhejiang,Quzhou 324000,China)

机构地区：[1]浙江省衢州市第二人民医院麻醉科,浙江衢州324000 [2]温州医科大学附属衢州医院,衢州市人民医院麻醉科,浙江衢州324000

出　　处：《中国医药科学》2023年第21期167-170,共4页China Medicine And Pharmacy

基　　金：浙江省医学会临床科研基金项目(2020ZYC-A129);浙江省医师协会临床研究基金项目(YS2021-1-001)。

摘　　要：目的比较甲苯磺酸瑞马唑仑和丙泊酚在食管内镜黏膜下剥离术中用于麻醉镇静时的血流动力学稳定性。方法选择2021年1月至2022年9月浙江省衢州市第二人民医院内镜下食管黏膜剥脱术患者60例,按照随机数表法分为试验组(瑞马唑仑组,n=30)和对照组(丙泊酚组,n=30)。记录两组患者手术时间、苏醒时间、住院时间及不良反应,比较两组患者的收缩压(SBP)、舒张压(DBP)、心率(HR)及血氧饱和度(SpO_(2))。结果试验组的手术时间、苏醒时间以及住院时间均短于对照组,差异有统计学意义(P<0.05)。试验组T2、T3、T4的SBP、DBP、HR以及SpO_(2)均高于对照组,差异有统计学意义(P<0.05)。试验组的不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。结论甲苯磺酸瑞马唑仑应用于食管内镜黏膜下剥离术中,对血流动力学影响较小,手术时间、苏醒时间以及住院时间较短,且不良反应发生率较小。Objective To investigate the hemodynamic stability of remimazolam tosilate compared with propofol in anesthesia sedation of esophageal endoscopic submucosal dissection.Methods A total 60 patients who underwent esophageal endoscopic submucosal dissection in the Second People’s Hospital of Quzhou,Zhejiang from January 2021 to September 2022 were allocated into two groups by random number table method,the experimental group(remimazolam group,n=30)and the control group(propofol group,n=30).The operation time,awakening time,hospital stay and adverse reactions of the two groups were recorded,the systolic blood pressure(SBP),diastolic blood pressure(DBP),heart rate(HR)and saturation of peripheral Oxygen(SpO_(2))were compart between the two groups.Results The experimental group exhibited significantly reduced duration of the operation,awakening time,and hospital stay compared to the control group(P<0.05).Additionally,the experimental group exhibited higher SBP,DBP,HR,and SpO_(2) compared with the control group,with statistically significant differences(P<0.05).The experimental group demonstrated a significantly lower incidence of adverse reactions as compared with the control group(P<0.05).Conclusion The use of remimazolam tosilate in esophageal ESD had minimal impact on hemodynamics,resulting in shorter operation time,awakening time,hospital stay,and fewer adverse reactions.

关 键 词：甲苯磺酸瑞马唑仑 丙泊酚 食管内镜黏膜下剥离术 血流动力学 

分 类 号：R614.2[医药卫生—麻醉学]