地佐辛注射液致人类免疫缺陷病毒感染患者成瘾1例分析  

One case of addiction induced by dezocine injection in a patient with HIV

作　　者：沈倩 张蕾 SHEN Qian;ZHANG Lei(Department of Pharmacy,Jiangsu Shengze Hospital Affiliated to Nanjing Medical University,Suzhou Jiangsu 215228,China)

机构地区：[1]南京医科大学附属江苏盛泽医院药学部,江苏苏州215228

出　　处：《中国药物警戒》2023年第10期1181-1183,共3页Chinese Journal of Pharmacovigilance

基　　金：2022年度“苏州市药学会-常州四药临床药学科研基金”研究项目(SKYXD2022011);苏州市吴江区“科教兴卫”项目(wwk201814)。

摘　　要：目的 探讨地佐辛注射液致人类免疫缺陷病毒感染患者成瘾不良反应及其影响因素分析,为临床上安全用药提供参考。方法 结合文献分析本院1例人类免疫缺陷病毒感染患者地佐辛注射液成瘾机制和影响因素。结果 地佐辛注射液成瘾机制与对μ受体有部分激动、抑制5-羟色胺重吸收和去甲肾上腺素再摄取、κ受体激动相关。本例患者连续使用地佐辛注射液40余天,用药疗程过长,剂量过大可使地佐辛成瘾的风险显著增加。结论 临床应用地佐辛注射液应严格把握适应证,防止滥用,避免长期使用。Objective To explore the adverse reactions to addiction caused by dezocine injection in an HIV patient and analyze the influencing factors so as to provide reference for clinical safety.Methods The clinical data of an HIV patient with dezocine injection addiction treated in our hospital was analyzed while the mechanism and influencing factors of dezocine injection addiction were discussed based on literature review.Results The mechanism of addiction to dezocine injection was related to partial activation of μ receptors,inhibition of serotonin reabsorption and norepinephrine reuptake,and κ receptor activation.This patient had been using dizocine injection for more than forty consecutive days.Too long a course of treatment and too high a dose could significantly increase the risk of addiction to dezocine.Conclusion In clinical application of dezocine injection,the indications should be strictly controlled to prevent abuse and avoid long-term use.

关 键 词：地佐辛 药物依赖性 镇痛治疗 人类免疫缺陷病毒 成瘾 

分 类 号：R971[医药卫生—药品] R994[医药卫生—药学]