华法林片联合复方氨酚烷胺片致凝血功能极度异常1例分析  

One case of extremely abnormal coagulation caused by warfarin combined with compound paracetamol and amantadine hydrochloride tablets

作　　者：张雯雯 聂西庭 徐会茹 冉晔[2] 田成林[2] 于生元[2] ZHANG Wenwen;NIE Xiting;XU Huiru;RAN Ye;TIAN Chenglin;YU Shengyuan(School of Medicine,Nankai University,Tianjin 300017,China;Department of Neurology,the First Medical Center of Chinese PLA General Hospital,Beijing 100853,China;Department of Neurology,Zhangdian People’s Hospital of Zibo,Zibo Shandong 255000,China)

机构地区：[1]南开大学医学院,天津300071 [2]解放军总医院第一医学中心神经内科,北京100853 [3]淄博市张店区人民医院神经内科,山东淄博255000

出　　处：《中国药物警戒》2023年第11期1290-1292,共3页Chinese Journal of Pharmacovigilance

基　　金：军队后勤科研重点项目(20BJZ38)。

摘　　要：目的探讨华法林片与复方氨酚烷胺片可能存在的不良药物相互作用。方法报道1例因静脉窦血栓而长期服用华法林的患者,间断服用复方氨酚烷胺片后出现凝血功能持续极度异常。结果患者经停用华法林、补充维生素K及凝血因子后凝血功能逐渐恢复。结论复方氨酚烷胺片或可明显增强华法林的抗凝效果,导致极高的出血风险,临床诊疗中需注意两药相互作用所致的不良反应,应谨慎合用,需密切观察出血情况和监测凝血功能。Objective To explore the possible adverse drug interactions between warfarin and compound paracetamol and amantadine hydrochloride tablets.Methods A patient who had been taking warfarin for a long time for venous sinus thrombosis was reported to have sustained extremely abnormal coagulation function after intermittent administration of compound paracetamol and amantadine hydrochloride tablets.Results The coagulation function of the patient recovered gradually after discontinuation of warfarin and supplementation of vitamin K and coagulation factors.Conclusion Compound paracetamol and amantadine hydrochloride tablets may significantly enhance the anticoagulant effect of warfarin,leading to an extremely high risk of bleeding.Clinicians should be alert to the interactions between the two drugs.Warfarin and cold medicine must be cautiously combined in clinical treatment,and bleeding and clotting function should be closely monitored.

关 键 词：华法林 复方氨酚烷胺 凝血功能 抗凝 药品不良反应 药物相互作用 

分 类 号：R972[医药卫生—药品] R994.11[医药卫生—药学]