依非韦伦致男性乳房发育1例分析  

One case of gynecomastia induced by efavirenz tablets

作　　者：唐炯 刘颖[2] TANG Jiong;LIU Ying(Department of Pharmacy,Chengdu Seventh People’s Hospital,Affiliated Cancer Hospital of Chengdu Medical College,Chengdu Sichuan 610213,China;Department of Pharmacy,The Third People’s Hospital of Chengdu,Affiliated Hospital of Southwest Jiaotong University,Chengdu Sichuan 610031,China)

机构地区：[1]成都市第七人民医院,成都医学院附属肿瘤医院药剂科,四川成都610213 [2]成都市第三人民医院药学部,四川成都610031

出　　处：《中国药物警戒》2023年第11期1306-1308,共3页Chinese Journal of Pharmacovigilance

摘　　要：目的 探讨非核苷类反转录酶抑制剂依非韦伦致男性乳房发育病例,为临床预防及处理其不良反应提供参考。方法 分析1例感染人类免疫缺陷病毒(HIV)男性患者服用依非韦伦导致乳房发育的治疗过程,探讨依非韦伦致乳腺增生的机理并排除其他药物的可能性。结果 患者服用依非韦伦后单侧乳房发育,停用该药并予以手术治疗2个月后,乳房不适减轻。结论 依非韦伦致男性乳房发育或与影响雌激素/雄激素的作用有关,用药期间应定期做乳房检查,做到早识别、早处理。Objective To explore one case of gynecomastia induced by efavirenz,and to provide reference for clinical prevention and treatment of the adverse reactions.Methods The process of treating one patient who had developed gynecomastia after taking efavirenz was analyzed in order to investigate the mechanism by which efavirenz caused gynecomastia and to rule out the possibility of other drugs.Results The patient developed unilateral gynecomastia after taking efaveranz.The breast discomfort was alleviated 2 months after withdrawal of efaveran and surgical treatment.Conclusion Gynecomastia caused by efavirenz may be related to the effect of estrogen/androgen.During medication,breasts should be examined regularly for the sake of early identification and treatment.

关 键 词：依非韦伦 男性乳房发育 人类免疫缺陷病毒 获得性免疫缺陷综合征 药品不良反应 抗逆转录病毒治疗 非核苷逆转录酶抑制剂 

分 类 号：R978[医药卫生—药品] R994.11[医药卫生—药学]