虾脊兰化学成分的研究  

Chemical constituents from Calanthe discolor

作　　者：简洁 吴其云 杨孝斌 缪丽兰 吴继春 JIAN Jie;WU Qi-yun;YANG Xiao-bin;MIAO Li-lan;WU Ji-chun(Guizhou University of Traditional Chinese Medicine,Guiyang 550025,China)

机构地区：[1]贵州中医药大学,贵州贵阳550025

出　　处：《中成药》2023年第11期3639-3643,共5页Chinese Traditional Patent Medicine

基　　金：贵州省教育厅青年科技人才成长项目(黔教合KY字[2018]204)。

摘　　要：目的研究虾脊兰Calanthe discolor Lindl.的化学成分。方法虾脊兰甲醇提取物采用聚酰胺、硅胶、MCI、反相C18、Sephadex LH-20进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到17个化合物,分别鉴定为羽扇豆醇乙酸酯(1)、3,5-二羟基戊-4-内酯(2)、甲基α-L-呋喃阿拉伯糖苷(3)、β-D-吡喃果糖(4)、2,4(1H,3H)-喹唑啉二酮(5)、5-羟基-2-羟甲基吡啶(6)、4-乙酰氨基丁酸(7)、2′-脱氧胸腺嘧啶核苷(8)、2′-脱氧尿嘧啶核苷(9)、2-(呋喃-2′-基)-5-(2″S,3″S,4″-三羟基丁基)-1,4-二嗪(10)、calanthoside(11)、ginsenine(12)、酒渣碱(13)、gardenifolin H(14)、山橘脂酸(15)、芦丁(16)、槲皮素-3-O-β-D-吡喃半乳糖苷(17)。结论化合物1~4、6~10、12~16均为首次从虾脊兰属植物中分离得到。AIM To study the chemical constituents from Calanthe discolor Lindl..METHODS The methanol extract from C.discolor was isolated and purified by polyamide,silica gel,MCI,reverse C 18 and Sephadex LH-20,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Seventeen compounds were isolated and identified as lupenyl acetate(1),3,5-dihydroxyl-4-valerolactone(2),methylα-L-arabinofuranoside(3),β-D-fructopyranose(4),2,4(1 H,3H)-quinazolinedione(5),5-hydroxyl-2-hydroxymethylpyridine(6),4-acetylaminobutanoic acid(7),2′-deoxythymidine(8),2′-deoxyuridine(9),2-(furan-2′-yl)-5-(2″S,3″S,4″-trihydroxybutyl)-1,4-diazine(10),calanthoside(11),ginsenine(12),flazin(13),gardenifolin H(14),glycosmisic acid(15),rutin(16),quercetin-3-O-β-D-galactopyranoside(17).CONCLUSION Compounds 1-4,6-10,12-16 are isolated from genus Calanthe for the first time.

关 键 词：虾脊兰 化学成分 分离鉴定 

分 类 号：R284[医药卫生—中药学]