动脉粥样硬化危险因素衰老、肥胖、生物钟紊乱与核糖体新生的研究进展  

Research progress of atherosclerosis risk factors like aging,obesity,circadian clock disorders and ribosome biogenesis

作　　者：张瑜 涂均楚 李玉洁 吴伟亮 韩青芳 焦丽娟 王燕丽 李杨欣 ZHANG Yu;TU Junchu;LI Yujie;WU Weiliang;HAN Qingfang;JIAO Lijuan;WANG Yanli;LI Yangxin(Institute for Cardiovascular Science,Suzhou Medical College of Soochow University&Department of Cardiovascular Surgery,the First Affiliated Hospital of Soochow University,Suzhou,Jiangsu 215123,China)

机构地区：[1]苏州大学、苏州医学院心血管病研究所、苏州大学附属第一医院心脏大血管外科,江苏省苏州市215123

出　　处：《中国动脉硬化杂志》2023年第11期921-928,共8页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金面上项目(82370264和81870194);国家自然科学基金重大研究计划项目(91849122);江苏省“六大人才高峰”创新团队项目(BU24600117);中国博士后基金(2021M702394);江苏省卓越博士后项目;放射医学与辐射防护国家重点实验室资助项目(GZK12023023)。

摘　　要：动脉粥样硬化是心脑血管疾病的主要原因,可能由吸烟、高血压、衰老、肥胖、生物钟紊乱等多因素导致。核糖体作为蛋白质合成的分子机器,维持细胞内蛋白质稳态。文章聚焦于衰老、肥胖和生物钟紊乱对动脉粥样硬化的影响,以及与核糖体新生的关系,为动脉粥样硬化的机制研究和防治提供理论支持。Atherosclerosis is the leading cause of cardiovascular and cerebrovascular diseases caused by smoking,hypertension,aging,obesity,circadian clock disorders,and other factors.As a molecular machine for protein synthesis,ribosomes maintain protein homeostasis in cells.This review focuses on the impact of aging,obesity,and circadian clock disorders on the development of atherosclerosis and the relationship with ribosome biogenesis and provides the theoretical basis for both basic research and clinical intervention of atherosclerosis.

关 键 词：动脉粥样硬化 核糖体新生 衰老 肥胖 生物钟紊乱 

分 类 号：R543.5[医药卫生—心血管疾病]