急性心肌梗死患者TyG指数与冠状动脉病变严重程度的相关性  

Correlation between TyG index and severity of coronary artery disease in patients with acute myocardial infarction

作　　者：陈艳丽 何雄 帕尔哈提·吐尔逊[2] CHEN Yanli;HE Xiong;PAERHATI·Tuerxun(Fourth Clinical Medical College of Xinjiang Medical University,Urumqi,Xinjiang 830000,China;Department of Cardiology,the Fourth Affiliated Hos-pital of Xinjiang Medical University,Urumqi,Xinjiang 830000,China)

机构地区：[1]新疆医科大学第四临床医学院,新疆乌鲁木齐市830000 [2]新疆医科大学第四附属医院心内科,新疆乌鲁木齐市830000

出　　处：《中国动脉硬化杂志》2023年第11期969-974,共6页Chinese Journal of Arteriosclerosis

基　　金：新疆维吾尔自治区自然科学基金面上项目(2022D01C165)。

摘　　要：[目的]探讨急性心肌梗死(AMI)患者甘油三酯-葡萄糖(TyG)指数与冠状动脉病变严重程度的相关性。[方法]回顾性选择2020年1月—2023年3月期间就诊于新疆医科大学第四附属医院确诊为AMI的424名患者作为研究对象,收集临床资料及冠状动脉造影(CAG)结果,Gensini评分用以定量评估冠状动脉病变程度。根据Gensini评分三分位法分为低Gensini评分组(<45分,n=140)、中Gensini评分组(45~86分,n=143)和高Gensini评分组(≥87分,n=141)。采用单因素和多因素Logistic回归模型分析TyG指数与高Gensini评分冠状动脉病变发生的关系;采用Spearman相关分析法分析TyG指数与AMI患者Gensini评分之间的相关性;采用ROC曲线分析TyG指数对冠状动脉病变严重程度的预测价值。[结果]高Gensini评分组TyG指数较低、中Gensini评分组明显升高(P<0.05)。Logistic回归分析显示,TyG指数为AMI患者严重冠状动脉病变发生的独立危险因素(OR=13.327,95%CI:2.642~67.235,P=0.002)。Spearman相关分析显示,TyG指数与冠状动脉病变严重程度呈正相关(r=0.331,P<0.001)。ROC曲线分析显示,TyG指数的曲线下面积为0.680(95%CI:0.630~0.731,P<0.001)。当TyG指数临界值取1.555时,其预测AMI患者发生严重冠状动脉病变风险的效能最高,灵敏度为79.4%,特异度为50.5%。[结论]TyG作为一种新型生物标志物,与AMI患者冠状动脉病变的严重程度显著且独立相关。Aim To investigate the correlation between triglyceride-glucose(TyG)index and the severity of coronary artery disease assessed in patients with acute myocardial infarction(AMI).Methods The study restrospectively selected 424 patients with AMI in the Fourth Affiliated Hospital of Xinjiang Medical University from January 2020 to March 2023.Clinical data and results of coronary angiography(CAG)were collected.Gensini score was used to quantitatively assess the degree of coronary artery stenosis.According to tertiles of the Gensini,the patients were classifified into three groups:low Gensini score group(<45 points,n=140),medium Gensini score group(45~86 points,n=143),and high Gensini score group(≥87 points,n=141).The associations between TyG index and the occurrence of coronary artery disease with high Gensini score by Logistic regression analysis;Spearman correlation was used to analyze the correlation between TyG index and Gensini score in AMI patients;ROC curve was used to analyze the value of TyG index in predicting the severity of coronary artery lesions.Results TyG index of high Gensini score group was significantly higher than that of low and medium Gensini score group(P<0.05).Logistic regression analysis showed that TyG index was an independent risk factor for severe coronary lesions in AMI patients(OR=13.327,95%CI:2.642~67.235,P=0.002).Spearman correlation analysis showed that TyG index was positively correlated with the severity of coronary artery disease(r=0.331,P<0.001).ROC curve analysis showed that the area under curve of TyG index was 0.680(95%CI:0.630~0.731,P<0.001).When the cut-off value of TyG index was 1.555,the predicted efficacy of of se-vere coronary artery disease in patients with AMI was the highest,with a sensitivity of 79.4%and a specificity of 50.5%.Conclusion TyG,as a novel biomarker,was significantly and independently associated with the severity of the coronary arteries in patients with AMI.

关 键 词：TyG指数 急性心肌梗死 冠状动脉病变严重程度 GENSINI评分 

分 类 号：R5[医药卫生—内科学]