基于数据挖掘探讨中医药内服防治近视的用药规律  

Medication Patterns for TCM Internal Treatment of Myopia Based on Data Mining

作　　者：黄莉红 张大铮[1,2] 刘敏 钟娟 刘穆颉鑫 钱柯宏 林见知 HUANG Lihong;ZHANG Dazheng;LIU Min;ZHONG Juan;LIU Mujiexi;QIAN Kehong;LIN Jian-zhi(Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China)

机构地区：[1]成都中医药大学,成都610075 [2]都江堰市医疗中心,成都611830 [3]成都市妇女儿童医学中心,成都610073 [4]成都中医大银海眼科医院,成都610084 [5]北京中医药大学,北京100029

出　　处：《中国中医眼科杂志》2023年第12期1109-1113,共5页China Journal of Chinese Ophthalmology

基　　金：国家中医药健康旅游示范区建设专项(202111)。

摘　　要：目的基于数据挖掘技术探讨中医药内服防治近视的用药规律。方法纳入自建库至2021年12月31日收录于中国知网、万方数据库、维普、中国生物医学文献数据库、中国专利信息网中关于中医药内治近视的临床研究文献。将涉及的中药名称进行规范化、统一化处理后,录入Microsoft Excel 2022软件建立数据库,利用SPSS软件对处理好的数据进行关联规则、聚类分析。结果(1)一般情况:共纳入文献210篇,包含方剂101个,涉及中药184味。四气以温性(59味,32.03%)最多,五味以甘味(78味,42.46%)最多,归经以肝经(39味,21.12%)用药最多。(2)高频中药用药频次:使用频次≥20的中药有16味,排名前5位的分别为枸杞子(56次,5.53%)、石菖蒲(53次,5.24%)、远志(44次,4.35%)、当归(34次,3.36%)、五味子(30次,2.96%)。(3)中药关联规则分析:关联度较高的3组组合分别为石菖蒲-远志;远志-党参、石菖蒲;石菖蒲-远志、枸杞子。(4)高频中药聚类分析:共得到5类组方,功效分别为开窍益智、滋补肝肾;敛肝明目、滋阴补血;益气和中、健脾和胃;养阴柔肝、生津润燥;益气养阴、疏肝明目。结论本数据挖掘研究不仅客观反映了中药内治近视的理法方药规律,以药循法,更为将来开展更多中医药防治近视的真实世界研究,提供了药物配伍新思路。OBJECTIVE Based on data mining method,to explore the medication rules of ancient Chinese medicine for the prevention and treatment of myopia.METHODS Clinical research literature on the internal treatment of myopia with Traditional Chinese Medicine(TCM)was collected from databases including CNKI,Wanfang database,VIP,CBMdisc,and CV-PAT from the establishment of database to January 1st,2022.After standerdizing and unifying the names of Chinese medicines involved,a database was established using Microsoft Excel 2022 software.SPSS Modeler 18.0 and SPSS Statistics 26.0 software were used to perform correlation analysis and cluster analysis on the processed data.RESULTS(1)General situation:A total of 210 articles were included,including 101 prescriptions and 184 Chinese medicines.The medicinal properties were mainly warm property(59 medicines,32.03%),the five flavors were mainly sweet(78 medicines,42.46%),and the pertained meridians were mostly liver meridian(39 medicines,21.12%).(2)Frequency of usage of high-frequency Chinese medicines:There were 16 Chinese medicines with a frequency of usage more than 20 times,and the top five are Lycium barbarum(56 times,5.53%),Acorus tatarinowii(53 times,5.24%),Polygala tenuifolia(44 times,4.35%),Angelica sinensis(34 times,3.36%),and Schisandra chinensis(30 times,2.96%).(3)Correlation analysis:The three combinations with high correlation are Acorus tatarinowii-Polygala tenuifolia;Polygala tenuifolia-Codonopsis pilosula,Acorus tatarinowii;Polygala tenuifolia,Lycium barbarum-Acorus tatarinowii;Wolfiporia cocos,Polygala tenuifolia-Acorus tatarinowii;Wolfiporia cocos,Acorus tatarinowii-Polygala tenuifolia.(4)Clustering analysis of high-frequency Chinese medicines:A total of five types of formulas were obtained,with the functions of regaining consciousness and nourishing liver and kidney,enhancing intelligence;Soothing liver and brightening eyes,nourishing Yin and blood;Nourishing blood and soothing liver,norishing Yin and ecpelling wind;Strengthening spleen and benefiting Qi;Benefiting

关 键 词：中医药 近视 用药规律 数据分析 

分 类 号：R276.7[医药卫生—中医五官科学]