铁死亡在视网膜缺血再灌注损伤中的作用及中药治疗的研究进展  

The Role of Ferroptosis in Retinal Ischemia-reperfusion Injury and Research Prog⁃ress in Traditional Chinese Medicine Treatment

作　　者：王晓璇 王彦 张铭连 王浩 韩龙辉 WANG Xiaoxuan;WANG Yan;ZHANG Minglian;WANG Hao;HAN Longhui(Hebei Medical University,Shijiazhuang 054001,China)

机构地区：[1]河北医科大学,石家庄050017 [2]河北省眼科医院,河北省眼科学重点实验室,河北省眼部疾病临床医学研究中心,邢台054001

出　　处：《中国中医眼科杂志》2023年第12期1166-1170,共5页China Journal of Chinese Ophthalmology

基　　金：河北省省级科技计划资助(20577706D)。

摘　　要：视网膜缺血再灌注会对人视网膜神经元造成重大的损伤,且现有干预措施疗效甚微。铁死亡是一种细胞程序性死亡,参与全身多个器官缺血再灌注的过程。本文对铁死亡理论的研究进展进行综述,发现其参与了视网膜缺血再灌注损伤的发生发展,铁死亡抑制剂可以保护视网膜损伤,但铁死亡相关机制研究如诱发途径的文献报道较少,尚处于萌芽阶段。中药在治疗视网膜缺血再灌注中具有多靶点、多通路的优势,可通过抑制铁死亡来干预视网膜缺血再灌注损伤。本文通过总结铁死亡在视网膜缺血再灌注损伤的作用,并分析相关的中药药理机制,可为临床治疗和药物研发提供新的思路。Retinal ischemia-reperfusion(I/R)inflicts significant damage to retinal neurons,and current intervention measures show minimal efficacy.Ferroptosis,a form of regulated cell death,plays a role in the process of systemic I/R in multiple organs.This article provides a review of the research progress on the theory of ferroptosis,discovering its involvement in the occurrence and development of retinal I/R injury.Inhibition of ferroptosis can protect against retinal damage.However,the literature on ferroptosis-related mechanisms,such as the pathways involved,is limited and in its early stages.Traditional Chinese Medicine(TCM)has the advantage of targeting multiple pathways,making it suitable for treating retinal I/R injury by intervening in ferroptosis.By summarizing the role of ferroptosis in retinal I/R injury and analyzing the pharmacological mechanisms of related Chinese medicines,this article provides new insights for clinical treatment and medicine development.

关 键 词：铁死亡 视网膜缺血再灌注 中药 作用机制 

分 类 号：R285.6[医药卫生—中药学]