益气活血类方药联合羟苯磺酸钙治疗NPDR疗效的Meta分析  

Meta-Analysis of the Therapeutic Efficacy of Tonifying Qi and Activating Blood For⁃mulas Combined with Calcium Dobesilate in Non-Proliferative Diabetic Retinopathy

作　　者：张翘 鞠援[2] ZHANG Qiao;JU Yuan(Changchun University of Chinese Medicine,Changchun 130117,China)

机构地区：[1]长春中医药大学,长春130117 [2]长春中医药大学附属医院,长春130021

出　　处：《中国中医眼科杂志》2023年第12期1183-1189,共7页China Journal of Chinese Ophthalmology

摘　　要：目的对益气活血类方药联合羟苯磺酸钙治疗非增殖期糖尿病视网膜病变(NPDR)的疗效进行Meta分析。方法检索PubMed、Embase、Web of Science、The Cochrane Library、中国知网、万方和维普数据库报道的益气活血类方药联合羟苯磺酸钙治疗NPDR的相关文献,检索时间为建库至2022年10月31日。采用Cochrane系统评价手册对纳入文献进行质量评估,RevMan 5.3对纳入文献的临床指标进行Meta分析。结果共纳入19篇文献,共计1,598例患者,其中联合治疗组791例,对照组807例。与对照组比较,联合治疗组的总有效率[RR=1.290,95%CI(1.230,1.360),Z=9.970,P=0.000]、视力[MD=0.110,95%CI(0.080,0.140),Z=8.090,P=0.000]、黄斑中心凹厚度[MD=-19.710,95%CI(-29.790,-9.670),Z=3.840,P=0.000)]、中医证候评分[SMD=-1.200,95%CI(-1.800,-0.600),Z=3.900,P=0.000)]、血清血管内皮生长因子[MD=-16.970,95%CI(-22.020,-11.910),Z=6.580,P=0.000]、全血高切黏度[MD=-0.440,95%CI(-0.740,-0.130),Z=2.820,P=0.005]、全血低切黏度[MD=-0.870,95%CI(-1.130,-0.610),Z=6.590,P=0.000]均有改善,差异有统计学意义,且未见严重不良反应。结论益气活血类方药联合羟苯磺酸钙治疗NPDR疗效显著,能提高患者总有效率,改善视力。OBJECTIVE To conduct a Meta-analysis to evaluate the therapeutic efficacy of tonifying Qi and activating blood formulas combined with calcium dobesilate in the treatment of non-proliferative diabetic retinopathy(NPDR).METHODS Relevant literature on the treatment of NPDR with tonifying Qi and activating blood formulas combined with calcium dobesilate was retrieved from PubMed,Embase,Web of Science,The Cochrane Library,CNKI,Wanfang,and VIP databases up to October 31st,2022.The Cochrane Handbook for Systematic Reviews was used for quality assessment,and RevMan 5.3 was employed for meta-analysis of clinical indicators in the included studies.RESULTS A total of 19 studies involving a total of 1,598 patients(791 in the combined treatment group and 807 in the control group)were included.Compared with the control group,the combined treatment group showed significant improvement in total effective rate[RR=1.290,95%CI(1.230,1.360),Z=9.970,P=0.000],visual acuity[MD=0.110,95%CI(0.080,0.140),Z=8.090,P=0.000],central macular thickness[MD=-19.710,95%CI(-29.790,-9.670),Z=3.840,P=0.000)],Traditional Chinese Medicine syndrome score[SMD=-1.200,95%CI(-1.800,-0.600),Z=3.900,P=0.000)],serum vascular endothelial growth factor[MD=-16.970,95%CI(-22.020,-11.910),Z=6.580,P=0.000],whole blood high shear viscosity[MD=-0.440,95%CI(-0.740,-0.130),Z=2.820,P=0.005],and whole blood low shear viscosity[MD=-0.870,95%CI(-1.130,-0.610),Z=6.590,P=0.000].The differences were statistically significant,and no severe adverse reactions were observed.CONCLUSIONS Tonifying Qi and activating blood formulas combined with calcium dobesilate significantly improve the efficacy of NPDR treatment,enhancing the total effective rate and improving visual acuity.

关 键 词：益气活血 羟苯磺酸钙 中西医结合 非增殖期糖尿病视网膜病变 

分 类 号：R276.7[医药卫生—中医五官科学]