Intestinal microbiota links to allograft stability after lung transplantation: a prospective cohort study  

作　　者：Junqi Wu Chongwu Li Peigen Gao Chenhong Zhang Pei Zhang Lei Zhang Chenyang Dai unpeng Zhang Bowen Shi Mengyang Liu Junmeng Zheng Bo Pan Zhan Chen Chao Zhang Wanqing Liao Weihua Pan Wenjie Fang Chang Chen 

机构地区：[1]Department of Thoracic Surgery,Shanghai Pulmonary Hospital,School of Medicine,Tongji University,Shanghai,China [2]Shanghai Engineering Research Center of Lung Transplantation,Shanghai,China [3]State Key Laboratory of Microbial Metabolism,School of Life Sciences and Biotechnology,Shanghai Jiao Tong University,Shanghai,China [4]Department of Thoracic Surgery,Changhai Hospital,Naval Medical University,Shanghai,China [5]Department of Thoracic Surgery,The First Affliated Hospital of Guangzhou Medical University,Guangzhou,China [6]Department of Cardiovascular Surgery,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou,China [7]Department of Dermatology,Shanghai Key Laboratory of Molecular Medical Mycology,Shanghai Changzheng Hospital,Naval Medical University,Shanghai,China [8]Adfontes(Shanghai)Bio technology Co.,Ltd,Shanghai,China

出　　处：《Signal Transduction and Targeted Therapy》2023年第10期4816-4824,共9页信号转导与靶向治疗（英文）

基　　金：This work was supported by the National Key Research and Development Program of China(2022YFC2504800);National Natural Science Foundation of China(Nos.82072257 and 82202543);Scientific and Technological Innovation action Plan of Science and Technology Commission of Shanghai Municipality(Nos.20DZ2253700,20DZ2272000,21410750500,and 22Y21900500);Shanghai Municipal Health Commission(shslczdzk01001);Guangxi Department of Science and Technology Foundation(No.2020GXNSFGA238001).

摘　　要：Whether the alternated microbiota in the gut contribute to the risk of allograft rejection(AR)and pulmonary infection(Pl)in the setting of lung transplant recipients(LTRs)remains unexplored.A prospective multicenter cohort of LTRs was identified in the four lung transplant centers.Paired fecal and serum specimens were collected and divided into AR,Pl,and event-free(EF)groups according to the diagnosis at sampling.Fecal samples were determined by metagenomic sequencing.

关 键 词：PROSPECTIVE LUNG ALLOGRAFT 

分 类 号：R655.3[医药卫生—外科学]