寄生虫抗药性及其对水产动物寄生虫病药物防治的启示  

PARASITE DRUG RESISTANCE AND ITS ENLIGHTENMENT FOR ANTHELMINTIC THERAPY OF PARASITIC DISEASES IN AQUACULTURE

作　　者：李文祥[1] 王浩[2] 习丙文[3] 李明[1] 聂品[1,4] 王桂堂 LI Wen-Xiang;WANG Hao;XI Bing-Wen;LI Ming;NIE Pin;WANG Gui-Tang(State Key Laboratory of Freshwater Ecology and Biotechnology,Institute of Hydrobiology,Chinese Academy of Sciences,Wuhan 430072,China;Shanghai Ocean University,Shanghai 201306,China;Freshwater Fisheries Research Center,Chinese Academy of Fishery Sciences,Wuxi 214081,China;Qingdao Agriculture University,Qingdao 266109,China)

机构地区：[1]中国科学院水生生物研究所淡水生态与生物技术国家重点实验室,武汉430072 [2]上海海洋大学,上海201306 [3]中国水产科学研究院淡水渔业研究中心,无锡214081 [4]青岛农业大学,青岛266109

出　　处：《水生生物学报》2024年第2期351-360,共10页Acta Hydrobiologica Sinica

基　　金：国家自然科学基金重点(32230109);国家大宗淡水鱼产业技术体系(CARS-45)资助。

摘　　要：抗药性是病原体在药物作用下发生生理变化和遗传变异而获得的能经受住药物毒性的一种能力。随着水产养殖集约化程度提高和药物长期大量使用,寄生虫抗药性越来越普遍和严重,不仅影响寄生虫病的防治效果,还带来环境污染和食品安全问题。文章通过对陆生动物抗寄生虫药物、寄生虫抗药性机制、抗药性主要测定方法、抗药性控制策略及水产动物寄生虫抗药性的研究现状进行综述,为我国水产养殖中寄生虫抗药性研究提供思路,同时为减缓寄生虫抗药性提供科学的防控策略。Drug resistance is the capacity of disease-causing pathogens to withstand drugs previously toxic to them,which is acquired by spontaneous mutation or through selective pressure after drug exposure.With the intensification of aquaculture and the extensive use of available compounds,parasite drug resistance has become more and more serious and widespread,which not only affects the efficacy of antiparasitic agents,but also brings about environmental pollution and food safety problems.This paper reviews the drugs for treating parasitic diseases of terrestrial animals,the mechanisms of drug resistance,the detecting assays of drug resistance,the treatment strategies to slow down the development of drug resistance,and the current status of parasite drug resistance in farming aquatic animals.This review aims to provide research framework for understanding parasite drug resistance and to propose effective treatment strategies for parasitic diseases in aquaculture in China.

关 键 词：寄生虫 杀虫药物 抗药性 水产动物 

分 类 号：S941.5[农业科学—水产养殖]