不同移植物在前交叉韧带翻修中的应用  

Application of different grafts in anterior cruciate ligament revision

作　　者：刘国立 李亮[1] 谢坤南 尹向辉[1] 张艳蕊[1] 易凡[1] 戴士峰[1] Liu Guoli;Li Liang;Xie Kunnan;Yin Xianghui;Zhang Yanrui;Yi Fan;Dai Shifeng(Department of Joint and Sports Medicine,The Second Hospital of Tangshan,Tangshan 063000,Hebei Province,China)

机构地区：[1]唐山市第二医院关节与运动医学科,河北省唐山市063000

出　　处：《中国组织工程研究》2024年第17期2647-2652,共6页Chinese Journal of Tissue Engineering Research

基　　金：河北省卫生健康科研基金项目(20221731),项目负责人:刘国立。

摘　　要：背景:前交叉韧带翻修过程中选用的移植物类型被认为是影响翻修术后效果的主要因素之一,但是关于不同移植物材料之间比较的报道较少。目的:探究自体韧带、同种异体韧带、LARS人工韧带用于前交叉韧带重建术后翻修的中长期临床疗效。方法:选择2011年5月至2020年5月唐山市第二医院关节科收治的前交叉韧带重建术后首次翻修患者67例,男41例,女26例,平均年龄(45.83±7.39)岁,根据翻修手术中移植物不同分3组:自体韧带组(n=24)、同种异体韧带组(n=22)与LARS人工韧带组(n=21)。翻修术后随访36个月以上,评估翻修效果。结果与结论:①3组患者术后1年与末次随访的国际膝关节文献委员会(IKDC)评分、Lysholm膝关节评分、Tegner运动评分均高于术前(P<0.05),3组间术后1年与末次随访的IKDC评分、Lysholm膝关节评分、Tegner运动评分比较差异均无显著性意义(P>0.05);②3组患者术后1年与末次随访的KT-1000侧侧差值均低于术前(P<0.05),LARS人工韧带组末次随访的KT-1000侧侧差值、轴移试验阳性率高于自体韧带组、同种异体韧带组(P<0.05);③末次随访影像学检测结果显示,重建骨隧道无明显扩大,移植物固定物无明显失效表现,骨关节炎无明显加重表现,但部分老年患者出现骨质密度降低;④结果表明,LARS人工韧带用于前交叉韧带翻修可提供较好的初始稳定性,但随着时间的延长,部分病例的稳定性趋于降低,甚至重建韧带失效;同种异体韧带与自体韧带用于前交叉韧带翻修均可获得较好的临床疗效。BACKGROUND:The type of graft selected during anterior cruciate ligament revision is considered one of the main factors affecting the postoperative outcome,but there are few reports on the comparison between different graft materials.OBJECTIVE:To explore the medium-to-long-term clinical efficacy after anterior cruciate ligament revision with autologous ligament,allogeneic ligament,and LARS artificial ligament.METHODS:A total of 67 patients with the first anterior cruciate ligament revision admitted to the Department of Joint and Sports Medicine,The Second Hospital of Tangshan from May 2011 to May 2020 were selected,including 41 males and 26 females,with a mean age of(45.83±7.39)years.They were divided into three groups according to different grafts used:autologous ligament group(n=24),allogeneic ligament group(n=22),and LARS artificial ligament group(n=21).Follow-up for more than 36 months after revision was performed to evaluate the effect of revision.RESULTS AND CONCLUSION:(1)International Knee Documentation Committee(IKDC)score,Lysholm knee score,and Tegner motor score 1 year after surgery and at the last follow-up in the three groups were higher than those before surgery(P<0.05).There were no significant differences in IKDC score,Lysholm knee score,and Tegner motor score among the three groups 1 year after surgery and the last follow-up(P>0.05).(2)The lateral differences of KT-1000 at 1 year after surgery and the last follow-up among the three groups were lower than those before surgery(P<0.05).The lateral difference of KT-1000 and the positive rate of the axial shift test in the last follow-up of the LARS artificial ligament group were higher than those in the autologous ligament group and allogeneic ligament group(P<0.05).(3)At the last follow-up,X-ray films showed no obvious enlargement of the reconstructed bone tunnel and no obvious failure of the graft fixation device.There was no obvious aggravation of osteoarthritis,but bone density decreased significantly in some elderly patients.(4)These findings sug

关 键 词：前交叉韧带重建 翻修手术 移植物 同种异体韧带 LARS人工韧带 关节镜 

分 类 号：R459.9[医药卫生—治疗学] R318.08[医药卫生—临床医学] R686