创面愈合中MXene纳米粒子的功能特性与临床应用  

Functional characteristics and clinical applications of MXene nanoparticles in wound healing

作　　者：王新冬 梁承志 张永先 Wang Xindong;Liang Chengzhi;Zhang Yongxian(Weifang Medical University,Weifang 261000,Shandong Province,China;Department of Orthopedic Trauma,College of Medicine,Qingdao University,Qingdao 266000,Shandong Province,China;Department of Osteotraumatic Surgery,960 Hospital of Chinese People’s Liberation Army Joint Logistics Support Force,Jinan 250031,Shandong Province,China)

机构地区：[1]潍坊医学院,山东省潍坊市261000 [2]青岛大学医学院创伤骨科,山东省青岛市266000 [3]中国人民解放军联勤保障部队第九六〇医院骨创伤外科,山东省济南市250031

出　　处：《中国组织工程研究》2024年第17期2739-2746,共8页Chinese Journal of Tissue Engineering Research

摘　　要：背景:MXene纳米粒子由于其独特的导电性、亲水性、抗菌性和生物相容性等特性使其作为皮肤伤口敷料有效功能成分具有非常可观的应用前景。目的:就MXene纳米粒子的合成方法、功能特性及其在皮肤损伤修复中的应用作一综述。方法:以“MXene,纳米粒子,纳米材料,生物活性纳米粒子”“伤口敷料,创面敷料,创面修复材料”“创面修复,伤口愈合,创面”为中文检索词检索万方和中国知网数据库,以“MXene,nanoparticles,nano-materials,Bioactive nanoparticles”“wound dressing,Wound healing material”“wound healing,wound repair,wound”为英文检索词检索PubMed数据库,最终纳入88篇文献进行综述分析。结果与结论:①MXene合成可分为自下而上合成和自上而下合成两种方法。合成后的MXene可以通过进一步表面修饰来增强生物相容性以便更好地应用于生物医学中。②MXene拥有一系列优异的特性如亲水性、抗菌性、光热性能、导电性及良好的生物相容性,这些特性都是使其成为出色的皮肤修复材料的基础。③目前已有许多学者开发出了用于制作伤口敷料的新型复合材料,目前来看这些复合材料基于MXene纳米材料并充分利用了其如前所述的优异特性,在皮肤创口局部起到了杀菌、载药缓释及主动调节细胞因子等作用,能够综合其他多种生物活性剂的优点,在伤口愈合中发挥了更好的作用,尤其适用于复杂慢性伤口的治疗。④以MXene的各种性能为基础研发出的各种复合材料如MXene@PVA水凝胶和MXene@CH海绵等,在改善组织修复性能、作为药物载体修复皮肤损伤方面展现出良好的作用,其在促进皮肤修复领域正处于发展的初始阶段且具有巨大的发展前景;目前MXenes纳米粒子的特性研究及表面改性研究已较为充分,但其剂量依赖的生物毒性分子机制研究相对不全面。BACKGROUND:MXene nanoparticles have considerable application prospects as effective functional components of skin wound dressings due to their unique properties of conductivity,hydrophilicity,antibacterial activity,and biocompatibility.OBJECTIVE:To review the synthesis methods,functional properties,and application of MXene nanoparticles in skin injury repair.METHODS:“MXene,nanoparticles,nanomaterials,bioactive nanoparticles”,“wound dressing,wound dressing,wound repair materials”,“wound repair,wound healing,wound surface”were used as Chinese search terms to search Wanfang and CNKI databases.“MXene,nanoparticles,nano-materials,bioactive nanoparticles”,“wound dressing,wound healing material”,“wound healing,wound repair,wound”were used as English search terms to search the PubMed database.Finally,88 articles were included for review analysis.RESULTS AND CONCLUSION:(1)MXene synthesis can be divided into two methods:bottom-up synthesis and top-down synthesis.The synthesized MXene can be further modified to enhance biocompatibility for better application in biomedicine.(2)MXene has a series of excellent properties such as hydrophilicity,antibacterial,photothermal properties,electrical conductivity,and good biocompatibility,all of which make it the basis for excellent skin repair materials.(3)At present,many scholars have developed new composite materials for wound dressings.Currently,these composite materials are based on MXene nanomaterials and make full use of its excellent characteristics as mentioned above,which play a role in local skin wound sterilization,drug delivery,and sustained release,active regulation of cytokines,and can integrate the advantages of other biologically active agents.It plays a better role in wound healing,especially in the treatment of complex chronic wounds.(4)Various composite materials such as MXene@PVA hydrogel and MXene@CH sponge developed based on various properties of MXene have shown good effects on improving tissue repair performance and repairing skin damage

关 键 词：MXene 纳米粒子 生物活性剂 生物相容性 创面敷料 组织修复 创面愈合 生物医学 

分 类 号：R459.9[医药卫生—治疗学] R363[医药卫生—临床医学] R364