基于MRI T2加权成像纹理分析评估青少年脊柱侧弯患者椎间盘退变的可行性研究  

The Feasibility of Texture-based Quantification for Evaluating Lumbar Intervertebral Disc Degeneration in Adolescent Idiopathic Scoliosis from Conventional T2-weighted Magnetic Resonance Imaging

作　　者：王凤仙 王守丰 常莹 周晋 陈静 周正扬[1] 王冬梅 WANG Fengxian;WANG Shoufeng;CHANG Ying;ZHOU Jin;CHEN Jing;ZHOU Zhengyang;WANG Dongmei(Department of Radiology,The Affiliated Hospital of Nanjing University Medical School,Nanjing 210008,China;Department of Orthopedic Surgery,Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School,Nanjing 210008,China;Department of Radiology,Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China)

机构地区：[1]南京大学医学院附属南京鼓楼医院放射科,南京210008 [2]南京大学医学院附属南京鼓楼医院骨科,南京210008 [3]上海中医药大学附属上海市中医医院放射科,上海200071

出　　处：《CT理论与应用研究（中英文）》2023年第6期735-745,共11页Computerized Tomography Theory and Applications

基　　金：江苏省六大人才高峰项目(2015-WSN-079);南京市医学科技发展基金重点项目;南京市医学杰出青年人才项目(YKK15067,QRX11178);江苏省重点医学青年人才、江苏省“十三五”健康促进工程(QNRC2016041);南京医学科技发展基金(YKK17099)。

摘　　要：目的:探讨MRI T2加权成像纹理分析在青少年脊柱侧弯患者椎间盘退变中的应用价值。材料和方法:从2016年10月至2020年3月,前瞻性纳入122例AIS患者和40名志愿者行3.0 T磁共振成像(MRI)检查并得到患者图像MRI纹理参数值:①平均值,②标准差,③最大值,④最小值,⑤第5、10、25、50、75和90百分位数,⑥偏度,⑦峰度,⑧熵。采用Pfirrmann评分对所有参与者的椎间盘进行评估并分组,AIS患者中,评分为Pm I的患者纳入1组,其余患者纳入2组,志愿者纳入0组;分析组间差异性和相关性。结果:2组的均值、标准差、最大值、熵和第5、10、25、50、75、90百分位均显著低于1组和0组;2组min显著低于0组;2组偏度显著高于1组和0组;2组峰度显著低于1组;1组偏度显著高于0组,1组标准差、最小值、峰度和第5、10、25、50百分位显著低于0组。结论:纹理分析可用于评估AIS患者椎间盘早期退行性改变,且优于常规MRI T2加权成像。Objective:To investigate the utility of texture data based on T2-weighted magnetic resonance imaging(MRI)in determining intervertebral disc degeneration in adolescent idiopathic scoliosis(AIS).Materials and Methods:From October 2016 and March 2020,122 patients with AIS and 40 volunteers who underwent 3.0T MRI were prospectively included.The following MRI texture data were generated:(1)mean,(2)standard deviation,(3)max,(4)min,(5)the fifth,10th,25th,50th,75th and 90th percentiles;(6)skewness;(7)kurtosis;and(8)entropy.The Pfirrmann system was used to evaluate the intervertebral discs of all participants.Patients with Pm I were divided into groups 1 and 2.Volunteers were classified into 0.Differences and correlations between the groups were analyzed.Results:The mean,standard deviation,max,entropy and the 5th,10th,25th,50th,75th,and 90th percentiles in group 2 were significantly lower than those in group 1 and group 0;the min in group 2 was significantly lower than in group 0;the skewness in group 2 was significantly higher than in group 1 and group 0;the kurtosis in group 2 was significantly lower than in group 1;the skewness in group 1 was significantly higher than in group 0 and the standard deviation,min,kurtosis and 5th,10th,25th,and 50th percentiles in group 1 were significantly lower than those in group 0.Conclusion:Texture analysis can be used to assess early degenerative changes in the intervertebral discs of patients with AIS.

关 键 词：MRI 纹理分析 青少年脊柱侧弯 椎间盘退变 

分 类 号：R45.2[医药卫生—治疗学]