主动脉缩窄新生儿的长期随访研究  

Long Term Outcomes of Neonates with Coarctation of Aorta

作　　者：黄梓健 王一飞 邹瑞坤 任媛 HUANG Zijian;WANG Yifei;ZOU Ruikun;REN Yuan(Guangdong Provincial People′s Hospital(Guangdong Academy of Medical Sciences),Southern Medical Univer-sity,Guangzhou 510080,China)

机构地区：[1]南方医科大学附属广东省人民医院(广东省医学科学院),广州510080

出　　处：《岭南心血管病杂志》2023年第4期391-394,共4页South China Journal of Cardiovascular Diseases

基　　金：广东省科技计划项目(项目编号:2019B020230003);广东省自然科学基金(项目编号:2020A1515010904)

摘　　要：目的本研究拟探讨主动脉缩窄(coarctation of aorta,CoA)新生儿的长期预后。方法对2013年至2019年在广东省人民医院诊断为CoA的新生儿进行随访,评估其长期预后情况。评估方法包括收集患儿门诊复诊、再次住院资料以及电话随访生长发育和心脏相关治疗情况。结果69例(男性72.4%)CoA新生儿完成了随访工作。随访年龄3.3(1.0~7.0)岁。单纯CoA 23例,复杂CoA 46例。6例单纯CoA患儿随访期间无需手术治疗。2例复杂CoA患儿接受CoA再次手术。两组患儿的出生情况及随访年龄比较,差异无统计学意义(P>0.05)。更多复杂CoA组患儿接受手术治疗(93.5%vs.73.9%,P=0.023)。虽然,两组间患儿随访时的体质量和身高比较,差异无统计学意义(P>0.05),但均低于正常值。与复杂CoA患儿比较,单纯CoA患儿的体质量指数Z值更低(-1.88±1.66 vs.-0.81±1.50,P=0.020)。结论CoA患儿学龄前的生长发育低于同龄儿童。虽然没有单纯CoA患儿出院后再接受手术治疗,CoA患儿的体质量/身高比Z值和体质量指数明显偏低。具体原因仍需要前瞻性大样本研究进一步探讨。Objectives To determine the long-term outcome of newborn infants with coarctation of aorta(CoA).Methods Newborn infants with CoA admitted to Guangdong Provincial People′s Hospital between 2013 and 2019 were followed up.Data of growth and cardiovascular interventions at follow-up clinics,readmissionor telephone visits were collected.Results The data of 69 infants(male 72.4%)were successfully collected,including 23 isolated CoA infants and 46 complicated CoA infants.The median age at follow-up was 3.3(1.0-7.0)years.Six isolated CoA infants didn′t need surgical intervention after birth.Two infants had reoperation for stenosis of aorta.There were no differences of weight and height at follow-up between isolated and complicated CoA infants.More infants had cardiac surgery in com⁃plicated CoA infants(93.5%vs.73.9%,P=0.023).There were no statistically significant difference of weight and height at follow-up between both groups(P>0.05),but weight and height in both groups were lower than normal values.The Z scores of body mass index(BMI)(-1.88±1.66 vs.-0.81±1.50,P=0.020)were lower in isolated CoA infants than those in complicated CoA infants.Conclusions CoA infants had poor growth at preschool age.Although no isolated CoA infants need surgical intervention after discharge,Z scores of weight to height ratio and BMI index of these infants are significant lower.The potential reason needs to be determined by prospective large sample size study.

关 键 词：主动脉缩窄 随访 生长发育 再手术 

分 类 号：R543.1[医药卫生—心血管疾病]