线叶报春苣苔化学成分研究  

Chemical Constituents from Primulina linearifolia(W.T.Wang)Yin Z.Wang

作　　者：罗彭[1] 邓祖帅 王佳佳[1] 沈章阳 潘为高[1] LUO Peng;DENG Zushuai;WANG Jiajia;SHEN Zhangyang;PAN Weigao(Guangxi University of Chinese Medicine,Nanning,Guangxi,530200,China)

机构地区：[1]广西中医药大学,广西南宁530200

出　　处：《广西科学》2023年第5期883-890,共8页Guangxi Sciences

基　　金：广西自然科学基金项目(2022JJA140371);广西高校中青年教师科研基础能力提升项目(2019KY0329);广西一流学科建设开放课题(2019XK047,2019XK132)资助。

摘　　要：为了研究广西地域特色壮药植物线叶报春苣苔[Primulina linearifolia(W.T.Wang)Yin Z.Wang]的化学成分,探索其传统药效的物质基础,本研究采用硅胶柱色谱、大孔树脂(D101)柱色谱、聚酰胺柱色谱、反相ODS柱色谱、Sephadex LH-20柱色谱和重结晶方法对其全草的乙醇提取物进行分离纯化,并根据波谱数据和理化性质鉴定化合物的结构。结果表明:从线叶报春苣苔全草的乙醇提取物中分离得到17个化合物,分别鉴定为二十七酸(1)、芥酸单甘油酯(2)、β-谷甾醇(3)、β-扶桑甾醇氧化物(4)、三十一烷酸对羟基苯乙酯(5)、香草酸(6)、熊果酸(7)、1-二十八酸甘油酯(8)、胡萝卜苷(9)、木通苯乙醇苷A(10)、5,7,3′,4′-四羟基-6-C-β-D-葡萄糖二氢黄酮碳苷(11)、大车前苷(12)、α-菠甾醇-3-O-β-D-葡萄糖苷(13)、1,8-二氮杂环十四烷-2,9-二酮(14)、24-三十四碳烯酸(15)、正三十四烷酸(16)、正四十二烷(17)。化学成分研究为该广西地域特色植物传统药效的物质基础研究、质量标准制定和深度开发应用提供了重要借鉴。Primulina linearifolia(W.T.Wang)Yin Z.Wang is a valuable Zhuang nationality medicinal crop at traditional herbs market.In order to identify its chemical basis for the traditional medicinal effects,silica gel column chromatography,macroporous resin(D101)column chromatography,polyamide column chromatography,ODS column chromatography,Sephadex LH20 column chromatography and recrystallization methods were applied in separation and purification of ethanol extract from the whole herb.Based on chemical properties and spectral analysis,17 compounds were characterized:Heptacosanoic acid(1),Monoerucin(2),β-Sitosterol(3),β-sitostenone(4),Hentriacontanoic acid,2-(4-hydroxyphenyl)ethyl ester(5),Vanillic acid(6),Ursolic acid(7),1-Octacosanoyl glyceride(8),Daucosterol(9),Calceolarioside A(10),5,7,3′,4′-tetrahydroxy-6-C-β-D-glucosyl-dihydroflavonol(11),Plantamajoside(12),α-spinasteryl-3-O-β-D-glucoside(13),1,8-diazacyclotetradecane-2,9-dinoe(14),n-Tetratriacont-24-enoic acid(15),n-Tetratriacontanoic acid(16),Alkane C42(17).This study will provide theoretical reference for the traditional medicine exploration.

关 键 词：线叶报春苣苔 分离纯化 化学成分 壮药 

分 类 号：R931.6[医药卫生—生药学]