早产儿生后7 d网织红细胞相关参数与贫血、胎龄、日龄的关系  

Relationship of the parameters related to reticulocyte with anemia,gestational age and day age in preterm infants 7 days after birth

作　　者：晏红 周雨露 王鉴 陈晓霞 YAN Hong;ZHOU Yulu;WANG Jian;CHEN Xiaoxia(Department of Neonatology,the Affiliated Hospital of Guizhou Medical University,Guiyang 550004,Guizhou,China)

机构地区：[1]贵州医科大学附属医院新生儿科,贵州贵阳550004

出　　处：《贵州医科大学学报》2023年第11期1399-1405,共7页Journal of Guizhou Medical University

基　　金：贵州省卫生健康委科学技术基金(gzwjkj2020-1-142)。

摘　　要：目的探讨早产儿出生后7 d网织红细胞(RET)相关参数与贫血、胎龄、日龄的关系。方法选取新生儿科收治的110例早产儿作为早产儿组,据胎龄分为极早早产儿组、中期早产儿组和晚期早产儿组,62例足月新生儿作为对照组;据早产儿生后7 d内是否贫血分为贫血组和非贫血组;分别在生后24 h内、第3及第7天时抽取静脉血液2 mL,检测全血标本中的血红蛋白(Hb)、RET比率(RET%)、RET绝对值(RET#)、RET He含量(Ret-He)、未成熟网织红细胞比率(IRF),比较这些指标在不同胎龄组、贫血组和非贫血组的变化。结果各早产儿组新生儿母亲孕期贫血发生率高于足月儿组(P<0.05),贫血组新生儿母亲孕期贫血发生率高于非贫血组(P<0.05);随着早产儿胎龄增加,各胎龄组出生时的Hb、Ret-He增加、IRF降低,生后第3天时RET%、RET#降低(P<0.05);随着日龄增加,各胎龄组都呈现Hb、RET%、RET#、IRF降低,Ret-He先降低、后增加(P<0.05);胎龄越小、贫血发生率越高,极早早产新生儿组贫血发生率高于其他胎龄组(P<0.05);随着日龄增加,非贫血组、贫血组早产新生儿RET%、RET#、Ret-He、IRF降低(P<0.05);与非贫血组同时间点比较,贫血组新生儿出生后第3天时RET%、RET#、IRF升高,Ret-He降低(P<0.05),出生后第7天时IRF升高,Ret-He降低(P<0.05)。结论胎龄越小,早产新生儿贫血发生率越高,IRF越高,Ret-He越低;随着日龄的增加,Hb、RET#、IRF及Ret-He均下降。Objective To analyze the relationship of parameters related to reticulocyte with anemia,gestational age,and day age in preterm infants 7 days after birth.Methods A total of 110 preterm infants in the department of neonatology were selected as the group of preterm infants.According to the gestational age,the preterm infants were divided into extremely preterm infants group,moderately preterm infants group and late preterm infants group,and 62 full term infants were selected as the control group.The preterm infants were also divided into anemic group and non-anemic group according to whether they were anemic within 7 days after birth.Two ml of venous blood was drawn in 24 hours after birth,on the 3 rd day and 7 th days after birth.The hemoglobin(Hb),reticulocyte ratio(RET%),absolute count of reticulocyte(RET#),reticulocyte hemoglobin content(Ret-He),and ratio of immature reticulocyte(IRF)in whole blood samples were detected by blood analyzer.The changes of these indexes were compared in different gestational age groups,anemic group and non-anemic group.Results The incidence of anemia during pregnancy in preterm infants in different gestational ages groups was higher than that in full term infants group(P<0.05),and the incidence of anemia during pregnancy in anemia group was higher than that in non-anemia group(P<0.05).With the increase of gestational age in preterm infants,the Hb and Ret-He increased,while IRF decreased at birth,RET%,and RET#decreased on the 3 rd day after birth(P<0.05).The Hb,RET%,RET#,and IRF of different gestational age groups in preterm infants on the 7th day after birth were lower than those of the same group in 24 hours and on the 3 rd day after birth(P<0.05).With the increase of age,the Hb,Ret%,RET#,and IRF decreased in all gestational age groups,and Ret-He decreased first and then increased.the incidence of anemia increased with the decrease of gestational age,and the incidence of anemia in extremely preterm infants group was significantly higher than that in other gestational age groups(P<

关 键 词：早产儿 贫血 胎龄 网织红细胞 网织红细胞血红蛋白含量 

分 类 号：R722[医药卫生—儿科]