脱羧氘化反应的研究进展  

Recent development of decarboxylative deuteration

作　　者：徐鑫 陈铁根 XU Xin;CHEN Tiegen(Shanghai Institute of Materia Medica,University of Chinese Academy of Sciences,Shanghai 201203;Zhongshan Institute for Drug Discovery,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Zhongshan Guangdong 528400)

机构地区：[1]中国科学院大学,中国科学院上海药物研究所,上海201203 [2]中科中山药物创新研究院,广东中山528400

出　　处：《首都师范大学学报（自然科学版）》2023年第6期68-82,112,共16页Journal of Capital Normal University：Natural Science Edition

基　　金：上海市自然科学基金面上基金项目(23ZR1474300);上海市青年科技启明星计划项目(21QA1411000);中山市社会公益与基础研究项目(2021B2014)。

摘　　要：氘标记的化合物在各领域中的应用日益广泛,开发新型氘代技术来获得各种有用的氘代化合物逐渐成为研究热点。羧酸及其衍生物因为便宜易得且性质稳定,常被用作起始原料来制备氘代化合物。为了系统地了解脱羧氘化反应的研究现状,为后续氘代策略研究指引方向,本文以烷基羧酸、芳基羧酸和α-羰基羧酸等为底物,对过去20年来有关脱羧氘化反应的研究进展进行了梳理和总结,证实了脱羧氘化反应是一种极具优势的氘化策略,且具有广阔的发展前景。Deuterium-labeled compounds find increasing application in various fields,and it has been a research hotspot to develop the new deuteration technology to obtain a variety of useful deuterated compounds.Carboxylic acids and their derivatives are usually used as raw materials to prepare deuterium-labeled compounds due to their cheap price,wide source and stable chemical property.To systematically review the development status of decarboxylative deuteration and identify the future research direction,the study has briefly summarized the research progress of decarboxylative deuteration during the past twenty years from aspects of alkyl carboxylic acid,aryl carboxylic acid,α-oxo carboxylic acid and so on as substrates,proving that decarboxylative deuteration is an excellent deuteration strategy with a bright prospect for wide applications.

关 键 词：氘代化合物 脱羧氘化 羧酸 

分 类 号：O6-1[理学—化学]