右美托咪定联合一氧化二氮吸入镇静下治疗儿童牙科恐惧症的疗效  

Efficacy of Dexmedetomidine Combined With Nitrous Oxide Inhalation Sedation in the Treatment of Dental Phobia in Children

作　　者：林颋旭 杨可以 林芝 赵福海 LIN Tingxu;YANG Keyi;LIN Zhi;ZHAO Fuhai(Department of Stomatology,Fuzhou Maternal and Child Health Hospital,Fuzhou Fujian 350008,China)

机构地区：[1]福州市妇幼保健院口腔科,福建福州350008

出　　处：《中国卫生标准管理》2023年第21期119-123,共5页China Health Standard Management

基　　金：福州市科技计划项目(2020-WS-89)。

摘　　要：目的 探讨右美托咪定联合一氧化二氮(笑气)吸入镇静下治疗儿童牙科恐惧症的临床疗效。方法 选取2022年5月—2023年5月在福州市妇幼保健院对牙科治疗有恐惧症的儿童120例,据简单随机分组将其分为笑气镇静组(实施笑气吸入镇静)、右美托咪定组(实施鼻吸入右美托咪定镇静)和联合组(实施鼻吸入右美托咪定联合笑气吸入镇静),各40例。比较各组的镇静效果、生命体征、患儿术中配合程度和治疗依从性、不良事件发生率等。结果 治疗15、30 min后,联合组镇静评分高于笑气镇静组和右美托咪定组,差异有统计学意义(P <0.05)。治疗15、30 min后,联合组的心率均低于笑气镇静组和右美托咪定组,差异有统计学意义(P <0.05)。治疗15 min后,联合组的血氧饱和度均高于笑气镇静组和右美托咪定组,差异有统计学意义(P <0.05)。治疗后,联合组术中配合度Houpt行为量表评分和Frankle治疗依从性评分明显高于笑气镇静组和右美托咪定组,差异有统计学意义(P<0.05)。治疗后三组的烦躁、恶心、嗜睡发生率相比,差异无统计学意义(P> 0.05)。结论 右美托咪定联合笑气吸入镇静下治疗儿童牙科恐惧症的效果较好,能减轻患儿的恐惧,提高患儿的治疗依从性和配合度。Objective To investigate the clinical efficacy of dexmedetomidine combined with nitrous oxide inhalation in the treatment of Dental fear in children.Methods A total of 120 children with dental phobia in Fuzhou Maternal and Child Health Hospital from May 2022 to May 2023 were selected and randomly divided into a laughing gas sedation group(implementing laughing gas inhalation sedation),a dexmedetomidine group(implementing nasal inhalation of dexmedetomidine sedation),and a combination group(implementing nasal inhalation of dexmedetomidine combined with laughing gas inhalation sedation).There were 40 children in each group,and the sedative effect,vital signs,and safety of each group were compared The degree of intraoperative cooperation and treatment compliance,as well as the incidence of adverse events,among others,among the patients.Results After 15 and 30 minutes of intervention,the sedation score of the combined group was higher than that of the laughing gas sedation group and the dexmedetomidine group,with a statistically significant difference(P<0.05).After 15,30 minutes of intervention,the heart rate of the combined group was lower than that of the laughing gas sedation group and the dexmedetomidine group,with a statistically significant difference(P<0.05).After 15 minutes of intervention,the blood oxygen saturation of the combined group was higher than that of the laughing gas sedation group and the dexmedetomidine group,with a statistically significant difference(P<0.05).There was no statistically significant difference in the incidence of irritability,nausea,and drowsiness among the three groups after treatment(P>0.05).Conclusion Dextrmedetomidine combined with nitrous oxide inhalation sedation is effective in the treatment of children's dental fear,which can reduce the fear of children and improve their treatment compliance and cooperation.

关 键 词：右美托咪定 笑气吸入 镇静 儿童 牙科恐惧症 治疗依从性 配合度 

分 类 号：R726[医药卫生—儿科]