Power of pee:Urine-derived stem cells in urological disorders  

作　　者：Pengfei Yu Emmanuel C.Opara Yuanyuan Zhang 

机构地区：[1]Institute for Regenerative Medicine,Wake Forest School of Medicine,Winston-Salem,North Carolina,USA

出　　处：《UroPrecision》2023年第1期38-44,共7页精准泌尿学（英文）

基　　金：Foundation for the National Institutes of Health,Grant/Award Numbers:R21 AI152832,R03 AI165170。

摘　　要：Given that urine-derived stem cells(USCs)originate from the urinary tract system,they hold great potential for treating urological disorders.USCs have several advantages over other types of stem cells,such as easy and noninvasive collection,and abundant supply.USCs can differentiate into different types of cells.This makes them a potential source of cells for tissue engineering and regenerative medicine in the field of urology.In animal models,USCs or USCderived exosomes regenerate damaged tissues in the treatment of various urological disorders such as urinary incontinence,bladder dysfunction,interstitial cystitis,urethra injury erectile dysfunction,and kidney injury via multiple differentiation potential,angiogenesis,anti-inflammatory,paracrine effects,and immune modulation capability.Overall,the use of USCs in urological disorders is a rapidly developing field,and ongoing research is needed to fully understand their potential applications.However,the early results are promising and suggest that USCs could become a valuable cell source for the treatment of various urological disorders in the future.

关 键 词：cell therapy stem cells tissue regeneration URINE urological diseases 

分 类 号：R699[医药卫生—泌尿科学]