国内B族链球菌定植的妊娠晚期孕妇妊娠结局的meta分析  

Pregnancy outcome of pregnant women in the third trimester of pregnancy colonized by streptococcus group B in China:A meta-analysis

作　　者：覃文琪 黄苏苏 湛璇 吴凯 李济填 Qin Wenqi;Huang Susu;Zhan Xuan;Wu Kai;Li Jitian(Department of Clinical Laboratory,Shenzhen University General Hospital,Shenzhen 518000,China)

机构地区：[1]深圳大学总医院检验科,广东深圳518000

出　　处：《实用妇科内分泌电子杂志》2023年第21期24-26,111,共4页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的根据国内报道的关于妊娠晚期孕妇B族链球菌(GBS)定植的妊娠结局研究进行meta分析,以期得到GBS引起的孕妇及新生儿不良结局的可靠证据,探索对于孕妇筛查分离培养GBS的意义和价值。方法在“CNKI中国知网”“Pubmed”“Cochrane”“Embase”多个数据库,检索时间为建库至2022年中国的相关研究,使用Review Manager 5.4软件进行meta分析。结果共计筛选8项研究,剖宫产、早产、胎膜早破、产后出血和产褥感染5个结局指标的综合OR值为2.94,95%的可信区间为(2.33,3.72)。新生儿窒息与新生儿住院的OR值分别为2.24、1.17,95%可信区间分别为(0.90,5.55)和(0.85,1.60)。胎儿窘迫与新生儿肺炎的OR值分别1.89、5.00,95%的可信区间为(1.17,3.05)和(1.82,13.74)。结论妊娠晚期GBS定植可能是妊娠不良结局的影响因素,在非感染性妊娠结局中其风险值需要进一步的研究,作为产褥感染以及新生儿败血症的风险因素可能更具有意义。妊娠晚期孕妇筛查分离培养GBS在预防孕妇和新生儿感染性疾病具有一定的意义和价值。Objective Based on the domestic reported pregnancy outcome studies on Group B streptococcus(GBS)colonization in pregnant women in the third trimester,a meta-analysis was conducted to obtain reliable evidence of adverse outcomes in pregnant women and newborns caused by GBS,and to explore the significance and value of screening,isolation and culture of GBS in pregnant women.Methods In CNKI,Pubmed,Cochrane and Embase databases,relevant Chinese studies from the establishment of the databases to 2022 were searched,and Review Manager 5.4 software was used for meta-analysis.Results A total of 8 studies were screened,and the combined OR value of 5 outcome indicators,cesarean section,premature delivery,premature rupture of membranes,postpartum hemorrhage and puerperal infection,was 2.94,with 95%confidence intervals(2.33,3.72).The OR values of neonatal asphyxia and neonatal hospitalization were 2.24 and 1.17,respectively,and 95%confidence intervals were(0.90,5.55)and(0.85,1.60),respectively.The OR values of fetal distress and neonatal pneumonia were 1.89 and 5.00,respectively,with 95%confidence intervals of(1.17,3.05)and(1.82,13.74).Conclusion GBS colonization in the third trimester may be an influential factor for adverse pregnancy outcomes,and its risk value in non-infectious pregnancy outcomes needs further study,which may be more significant as a risk factor for puerperal infection and neonatal sepsis.Screening,isolation and culture of GBs in pregnant women in the third trimester have certain significance and value in the prevention of infectious diseases in pregnant women and newborns.

关 键 词：B族链球菌 妊娠结局 META分析 

分 类 号：R714[医药卫生—妇产科学]