失血性休克后肾脏保护的研究进展  

Research progress of kidney protection after hemorrhagic shock

作　　者：刘洁[1] 李珺[1] 张晶玉 LIU Jie;LI Jun;ZHANG Jingyu(Department of Anesthesiology,The Second Hospital of Lanzhou University,Lanzhou 730050,China)

机构地区：[1]兰州大学第二医院麻醉科,甘肃兰州730050

出　　处：《精准医学杂志》2024年第1期84-87,共4页Journal of Precision Medicine

摘　　要：失血性抗休克是一种由于创伤等原因引起的临床常见的急危重症。尤其是肾脏在缺血缺氧后引起的局部组织灌注不足和细胞缺氧,极易导致急性肾损伤。临床上在不断探寻患者失血性休克后更安全、实用和有效的复苏方法,如从晶胶液体到高渗液体、从常压复苏到低压复苏、从纠正血压到恢复组织细胞的氧供、从维持血流动力学稳定到抑制细胞凋亡、从血管活性药到中药再到酶抑制剂的应用等等,以达到更好地保护肾脏的目的。本文就近年来关于失血性休克患者肾脏的保护研究进展进行综述。Hemorrhagic shock is a common acute and critical disease caused by trauma in clinic.In particular,local tissue hypoperfusion and cell hypoxia caused by renal ischemia and hypoxia can easily lead to acute kidney injury.In clinical practice,safer,practical,and effective resuscitation methods for patients with hemorrhagic shock are constantly explored to achieve the purpose of better protection of the kidney,such as the applications from colloidal crystal liquid to hypertonic fluid,from normal-pressure resuscitation to low-pressure resuscitation,from correcting blood pressure to restoring oxygen supply to tissue cells,from maintaining hemodynamic stability to inhibiting apoptosis,and from vasoactive drugs to Chinese traditional medicines to enzyme inhibitors.This article reviews the research progress of kidney protection for patients with hemorrhagic shock in recent years.

关 键 词：休克 出血性 肾脏 再灌注损伤 病因学 补液疗法 药物疗法 综述 

分 类 号：R692.5[医药卫生—泌尿科学]