有机化学综合实验“1-苄基-2-苯基苯并咪唑的合成”设计  

Organic Chemistry Comprehensive Experiment:Synthesis of 1-Benzyl-2-Phenylbenzimidazole

作　　者：徐彦芹[1] 刘敏[1] 马侑才 陈裕豪 李鑫 张晓慧 熊燕[1] XU Yanqin;LIU Min;MA Youcai;CHEN Yuhao;LI Xin;ZHANG Xiaohui;XIONG Yan(School of Chemistry and Chemical Engineering,Chongqing University,Chongqing 401331,China)

机构地区：[1]重庆大学化学化工学院,重庆401331

出　　处：《实验科学与技术》2023年第5期27-32,共6页Experiment Science and Technology

基　　金：2022年教育部产学研合作协同育人项目(220900575222005);2023年重庆市高等教育教学改革研究项目(233010)。

摘　　要：针对教材中有机化学综合实验氧化还原类项目反应温度较高、易产生有毒有害气体、副反应多、产率不高、产品回收困难等问题,设计了“1-苄基-2-苯基苯并咪唑的合成”实验。实验项目具有较强的综合性,包含了有机化学实验基本操作及柱层析、薄层色谱、熔点测定及核磁表征,采用ChemDraw、MestReNova等软件制图、谱图解析等对数据处理分析。此实验项目适用于本科大三(下)或者大四(上),有效避免了当前有机化学综合实验氧化还原实验项目中存在的一些问题,使化学化工类相关专业本科生的综合实验能力得到锻炼。Aiming at the problems of high reaction temperature,easy to produce toxic and harmful gases,many side effects,low yield,and difficult product recovery of organic chemistry comprehensive experiments in the textbook,the experiment of“Synthesis of 1-Benzyl-2-Phenylbenzimidazole”was designed.This experiment had strong comprehensiveness,including the basic operation of organic chemical experiment and column chromatography,thin layer chromatography(TLC),melting point determination and nuclear magnetic determination,and ChemDraw,MetReNova and other software were used to analyze and process data.This experiment is suitable for senior undergraduates,which effectively avoids some problems existing in the current organic chemistry comprehensive experiment oxidation and reduction experimental project,so that the comprehensive experimental ability of undergraduates majoring in chemical industry can be exercised.

关 键 词：有机化学综合实验 氧化还原反应 N N'-二苄基邻苯二胺 2 3-二氯-5 6-二氰基-1 4-苯醌 1-苄基-2-苯基苯并咪唑 

分 类 号：O657.39[理学—分析化学]