去细胞同种异体神经一期修复治疗毁损性断指再植指神经缺损的临床研究  

A clinical study on the treatment of nerve defect caused by disfiguring severed finger replantation with acellular allogeneic nerve in one stage repair

作　　者：李日绍[1] 关术[1] LI Rishao;GUAN Shu(Hand-foot Microsurgery Department,Maoming People’s Hospital,Maoming 525000,China)

机构地区：[1]茂名市人民医院手足显微外科,广东茂名525000

出　　处：《当代医药论丛》2023年第22期10-12,共3页

摘　　要：目的:研究在毁损性断指再植指神经缺损的治疗中应用去细胞同种异体神经一期修复的作用。方法:择取2020年1月—2023年1月茂名市人民医院收治的20例毁损性断指再植指神经缺损病例,以随机数字表法为依据将其分为对照组和观察组,每组10例。对照组实施神经松解缝合或自体腓肠神经移植,观察组实施去细胞同种异体神经一期修复,通过门诊复查、上门随访、电话随访三种途径收集患者感觉功能恢复情况数据,随访时间6个月以上,同时观察两组临床疗效、不良反应发生情况。结果:观察组总有效率略高于对照组,但组间比较差异无统计学意义(P>0.05)。观察组感觉功能恢复的总优良率略高于对照组,但组间差异无统计学意义(P>0.05)。两组均未出现感染及排斥等不良反应,相关差异无统计学意义(P>0.05)。结论:在毁损性断指再植指神经缺损的治疗中,应用去细胞同种异体神经一期修复的效果确切,而且安全性良好,临床价值显著。Objective:To study the effect of decellularized nerve allogeneic nerve repair in the treatment of nerve defect caused by disfigurement severed finger replantation.Methods:A total of 20 cases of finger nerve defect treated in Maoming People’s Hospital from January 2020 to January 2023 were selected and divided into control group and observation group according to random number table method,with 10 cases in each group.The control group received nerve release suture or autogenous sural nerve transplantation,and the observation group received cellless allogeneic nerve repair in one stage.Data on sensory function recovery of patients were collected through outpatient review,home follow-up and telephone follow-up for more than 6 months,and the clinical efficacy and adverse reactions of the two groups were observed.Results:The total effective rate of the observation group was slightly higher than that of the control group,but there was no statistical significance between groups(P>0.05).The total excellent and good rate of sensory function recovery in the observation group was slightly higher than that in the control group,but there was no statistical significance between the groups(P>0.05).There were no adverse reactions such as infection and rejection between the two groups,and there was no statistical significance(P>0.05).Conclusion:In the treatment of nerve defect caused by replantation of damaged severed finger,acellular nerve allograft is effective,safe and of significant clinical value.

关 键 词：去细胞同种异体神经 一期修复 毁损性断指再植 指神经缺损 安全性 

分 类 号：R616.2[医药卫生—外科学]