原发性胆汁性胆管炎肝血流超声参数与肝功能指标的相关性分析  

Correlation analysis of hepatic blood flow ultrasonic parameters and liver function indexes in primary biliary cholangitis

作　　者：商宁[1] 黄秀香[2] 叶迎宾 张嫄[4] SHANG Ning;Huang Xiu-xiang;YE Ying-bin;ZHANG Yuan(Department of Ultrasound Diagnostic,Handan Infectious Disease Hospital,Handan Hebei 056002;Department of Liver Disease,Handan Infectious Disease Hospital,Handan Hebei 056002;Department of Laboratory,Handan Infectious Disease Hospital,Handan Hebei 056002;Department of Ultrasound,Beijing You′an Hospital,Capital Medical University,Beijing 100054,China)

机构地区：[1]河北省邯郸市传染病医院功能科,056002 [2]河北省邯郸市传染病医院肝病科,056002 [3]河北省邯郸市传染病医院检验科,056002 [4]首都医科大学附属北京佑安医院超声科,北京100054

出　　处：《蚌埠医学院学报》2023年第11期1573-1576,共4页Journal of Bengbu Medical College

基　　金：北京佑安医院中青年人才孵育项目(BJYAYY-GG2019-05);河北省医学科学研究课题计划(20220476)。

摘　　要：目的:分析原发性胆汁性胆管炎(PBC)病人肝血流超声参数与肝功能指标的相关性。方法:选取原发性胆汁性胆管炎病人80例(PBC组)和正常体检者30名(对照组),均进行超声血流学检查和肝功能检测,分析超声血流学参数和肝功能指标的相关性。结果:PBC组病人血清天门冬氨酸氨基转移酶(AST)、碱性磷酸酶、γ-谷氨酰转肽酶(γ-GGT)、球蛋白水平均明显高于对照组(P<0.01),白蛋白、胆碱酯酶水平均明显低于对照组(P<0.01);PBC组肝静脉s波峰值流速(PVs)、d波峰值流速(PVd)均明显高于对照组(P<0.01),而肝动脉参数肝动脉收缩期最高峰值血流速度(PSV)和肝动脉舒张末期最低血流速度(EDV)均低于对照组(P<0.05),2组PVs与PVd比值(s/d)和肝动脉阻力指数(HARI)差异均无统计学意义(P>0.05)。PBC不同分期病人年龄、性别和PSV、EDV及AST、γ-GGT、白蛋白、CHE间差异均有统计学意义(P<0.05~P<0.01),而PVs、PVd、s/d、HARI、碱性磷酸酶、球蛋白间差异均无统计学意义(P>0.05)。PBC病人AST与PVs、PVd、PSV、EDV均呈明显正相关关系(P<0.05),HARI与γ-GGT呈明显负相关关系(P<0.05)。结论:PBC病人的肝血流超声参数与肝功能指标具有相关性,可为临床评估PBC疾病进展提供参考。Objective:To analyze the correlation between hepatic blood flow ultrasonic parameters and liver function indexes in patients with primary biliary cholangitis(PBC).Methods:A total of 80 patients with PBC(PBC group)treated and 30 patients in the normal physical examination(control group).Ultrasonic blood flow examination and liver function test were examined in all patients,and the corresponding correlation between blood flow parameters and liver function indicators was further analyzed.Results:The levels of serum AST,ALP,γ-GGT and GLO in the PBC group were higher than those in the control group(P<0.05),and ALB and CHE were lower than those in the control group(P<0.05).The hepatic vein parameters PVs and PVd in the PBC group were significantly higher than those in the control group(P<0.05),while the hepatic artery parameters PSV and EDV were lower than those in the control group(P<0.05),and there were no statistical significance in s/d and RI in PBC group(P>0.05).There were statistically significant differences in age,sex,PSV,EDV,and AST,γ-GGT,ALB and CHE among patients with PBC at different stages(P<0.05),while there were no statistically significant differences in PVs,PVd,s/d,HARI,ALP and GLO(P>0.05).The age of patients in stageⅣwas higher than that in other stages(P<0.05),and the PSV and EDV in stageⅢwere higher than those in stageⅠand stageⅣ(P<0.05).AST was positively correlated with PVs,PVd,PSV and EDV in PBC patients(P<0.05),while HARI was negatively correlated withγ-GGT(P<0.05).Conclusions:Hepatic blood flow ultrasound parameters of PBC patients are correlated with liver function indexes,which can provide a reference basis for the clinical evaluation of PBC disease progression.

关 键 词：胆管炎 肝血流超声 肝功能指标 

分 类 号：R657.45[医药卫生—外科学]