基于“土壅木郁”理论探讨溃疡性结肠炎合并情志不畅的发病机制及中医辨治思路  

Pathogenesis,traditional Chinese medicine syndrome differentiation and treatment strategies for ulcerative colitis complicated with emotional dysfunction based on the theory of earth accumulation causing wood stagnation

作　　者：孟凡艳 张杨[2] 柳越冬[3] MENG Fanyan;ZHANG Yang;LIU Yuedong(Liaoning University of Traditional Chinese Medicine,Shenyang,Liaoning 110000,China;The First Hospital of China Medical University,Shenyang,Liaoning 110001,China;The Third Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang,Liaoning 110032,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110000 [2]中国医科大学附属第一医院,辽宁沈阳110001 [3]辽宁中医药大学附属第三医院,辽宁沈阳110032

出　　处：《上海中医药杂志》2023年第12期55-58,共4页Shanghai Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(82074449)。

摘　　要：基于“土壅木郁”理论探讨溃疡性结肠炎(UC)合并情志不畅的发病机制,认为“土壅木郁”是UC合并情志不畅的关键病机。炎症堆积、肠道菌群紊乱、脑肠肽异常分泌能够在一定程度上反映土壅状态,并通过进一步作用导致肝郁,进而影响UC合并情志不畅的发生发展。治疗时应注重恢复脾运、通畅气机,积极干预情志因素。并附验案1则。Based on the theory of earth accumulation causing wood stagnation,this article discusses the pathogenesis of ulcerative colitis(UC)complicated with emotional dysfunction,proposing that earth accumulation causing wood stagnation is a key pathogenesis in the development of UC complicated with emotional dysfunction.Inflammation accumulation,gut microbiota dysbiosis,and abnormal secretion of brain-gut peptides partially reflect the state of earth accumulation,which further leads to the liver stagnation,and affects the development and progression of UC complicated with emotional dysfunction.During treatment,attention should be paid to restoring the transporting and transforming function of the spleen,promoting smooth qi circulation,and actively intervening in emotional factors.Additionally,a proven case is included.

关 键 词：溃疡性结肠炎 肝郁脾虚证 病因病机 焦虑 抑郁 肠道菌群 中医药疗法 

分 类 号：R259[医药卫生—中西医结合]