缺血性心脏病促血管生成治疗方法的研究进展  

Advances in treatment methods of angiogenesis induced by ischemic heart disease

作　　者：张雪(综述) 柳美兰(审校) ZHANG Xue;LIU Mei-lan(Department of Cardiovascular Medicine,Affiliated Hospital of Yanbian University,Jilin 133000,China)

机构地区：[1]延边大学附属医院心血管内科,吉林133000

出　　处：《中国临床新医学》2023年第11期1200-1204,共5页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：国家自然科学基金项目(编号:8196020325)。

摘　　要：缺血性心脏病(IHD),也称为冠心病,是由冠状动脉狭窄或阻塞引起的一组疾病。治疗IHD诱导血管生成和血管重建至关重要。近年来研究表明,外泌体可以通过促进血管生成,从而减轻心肌缺血再灌注损伤,抑制纤维化和促进心脏再生等作用,对IHD具有保护作用。促血管生成的研究可能为IHD的治疗提供新的选择。该文对IHD促血管生成治疗方法的研究进展作一综述。Ischemic heart disease(IHD),also known as coronary heart disease,includes a group of diseases caused by coronary artery stenosis or obstruction.It is crucial to treat IHD-induced angiogenesis and vascular reconstruction.In recent years,researches have shown that exosomes can alleviate myocardial ischemia-reperfusion injury,inhibit fibrosis,and promote heart regeneration by promoting angiogenesis,which has a protective effect on IHD.Researches on promoting angiogenesis may provide new options for the treatment of IHD.In this paper,the advances in the treatment methods of angiogenesis induced by IHD is reviewed.

关 键 词：缺血性心脏病 新血管形成 血管内皮生长因子 干细胞 外泌体 

分 类 号：R453[医药卫生—治疗学]