基于铁死亡作用机制探讨中医药干预脑缺血再灌注损伤  

Effect of Traditional Chinese Medicine on Cerebral Ischemia-Reperfusion Injury Based on Mechanism of Ferroptosis

作　　者：姚慧芳 蔚懿 王璐 关运祥[2] 钱仁义[2] YAO Huifang;WEI Yi;WANG Lu;GUAN Yunxiang;QIAN Renyi(The First Clinical Medical College of Henan University of Chinese Medicine,Zhengzhou Henan China 450000;The First Affiliated Hospital to Henan University of Chinese Medicine,Zhengzhou Henan China 450000)

机构地区：[1]河南中医药大学第一临床医学院,河南郑州450000 [2]河南中医药大学第一附属医院,河南郑州450000

出　　处：《中医学报》2023年第12期2567-2574,共8页Acta Chinese Medicine

基　　金：河南省中医药科学研究专项资助项目(2018ZY2073)。

摘　　要：铁死亡参与了脑卒中、脑缺血性再灌注损伤(cerebral ischemia reperfusion injury,CIRI)、神经退行性疾病的发生发展。CIRI具有高致残率、高病死率,严重影响患者的生存质量、生存周期。抑制system Xc^(-)/p53-GSH-GPXs、FSP1/CoQ10、GCH1-BH4-DHFR 3条核心通路介导的铁死亡可减轻患者的CIRI,而中医药具有多机制、多靶点、多层次的独特优势,可精准干预CIRI后铁死亡、减少神经功能的损伤。当前,中医药关于铁死亡机制的相关研究多集中在中药活性成分方面,今后的研究可探讨中药复方及其制剂、针灸研究等中医药疗法干预CIRI的作用机制,以进一步促进中医药精准干预CIRI研究。Ferroptosis is involved in the occurrence and development of stroke,cerebral ischemia-reperfusion injury(CIRI)and neurodegenerative diseases.CIRI has a high disability rate and mortality rate,which seriously affects the quality of life and survival cycle of patients.Inhibiting the ferroptosis mediated by the three core pathways of system Xc^(-)/p53-GSH-GPXs,FSP1-/CoQ10,and GCH1-BH4-DHFRs can reduce patients'CIRI.Traditional Chinese medicine for pediatrics has unique advantages of multiple mechanisms,targets,and levels,which can accurately intervene in ferroptosis after CIRI and reduce neurological damage.Currently,research on the mechanism of ferroptosis in traditional Chinese medicine is mostly focused on the active ingredients of traditional Chinese medicine.Future research can explore the mechanism of Chinese medicine therapy intervention in CIRI,such as Chinese medicine compound and its preparations,acupuncture and moxibustion research,to further promote the precise intervention of Chinese medicine in CIRI research.

关 键 词：脑缺血再灌注损伤 铁死亡 中医药 

分 类 号：R285.6[医药卫生—中药学]