紫草油联合化瘀生肌方对老年压力性损伤患者创面愈合时间及血管内皮生长因子表达的影响  

Effects of comfrey oil combined with Huayu Shengji formula on wound healing time and expression of VEGF in aged patients with iatrogenic stress injury

作　　者：梁姣[1] 袁雯 王晓娟[1] LIANG Jiao;YUAN Wen;WANG Xiaojuan(Xinjiang Medical University Affiliated Traditional Chinese Medicine Hospital,Urumqi 830054,China)

机构地区：[1]新疆医科大学附属中医医院,新疆乌鲁木齐830054

出　　处：《陕西中医》2023年第12期1722-1725,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：新疆维吾尔自治区重点研发计划项目(2021B03006);新疆医科大学附属中医医院课题(ZYY201924)。

摘　　要：目的:分析紫草油联合化瘀生肌方对3~4期老年压力性损伤创面愈合时间、炎性因子、血管内皮生长因子(VEGF)表达的影响。方法:选取3~4期老年压力性损伤患者92例纳入研究,随机分为对照组(化瘀生肌方治疗)、观察组(紫草油联合化瘀生肌方治疗),每组46例。观察两组治疗前、治疗2个月的中医症候积分、压疮愈合程度评分及VEGF、炎性因子水平。统计两组临床疗效、肉芽组织出现时间、创面愈合时间以及不良反应。结果:与对照组治疗后相比,观察组治疗总有效率较高(P<0.05)。与对照组比较,观察组中医症候积分与压疮愈合程度评分较低(均P<0.05)。与对照组比较,观察组肉芽组织出现时间、创面愈合时间较短(均P<0.05)。治疗后,观察组创面组织表皮生长因子(EGF)、碱性成纤维细胞生长因子(bFGF)、血管内皮生长因子(VEGF)水平高于对照组,炎性因子肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、C反应蛋白(CRP)水平低于对照组(均P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:紫草油与化瘀生肌方联合治疗不仅可以有效改善3~4期老年压力性损伤患者中医症候积分与压疮愈合程度评分,还能降低机体炎症因子水平,提高VEGF表达,缩短创面愈合时间。Objective:To analyze the effects of comfrey oil combined with Huayu Shengji formula on wound healing time,expression of inflammatory factors and VEGF in aged patients with iatrogenic stress injury in stage 3 to 4.Methods:A total of 92 elderly patients with stage 3 to 4 pressure injury were included in the study,they were randomly divided into control group(Huayu Shengji formula treatment)and observation group(comfrey oil combined with Huayu Shengji formula treatment),with 46 cases in each group.TCM syndrome score,pressure sore healing degree score,VEGF and inflammatory factor levels were observed before treatment and two months after treatment.The clinical efficacy,granulation time,wound healing time and adverse reactions of the two groups were analyzed.Results:Compared with the control group,the total effective rate of the observation group was higher(P<0.05).Compared with control group,TCM syndrome score and pressure sore healing degree score of observation group were lower(P<0.05).Compared with the control group,the granulation formation time and wound healing time of observation group were shorter(all P<0.05).After treatment,the levels of EGF,bFGF and VEGF in observation group were higher than those in control group,and the levels of inflammatory factors TNF-α,IL-6 and CRP were lower than those in control group(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The combined treatment of comfrey oil and Huayu Shengji formula can not only effectively improve the TCM syndrome score and pressure sore healing degree score of elderly patients with pressure injury in stage 3 to 4,but also reduce the level of inflammatory factors,increase the expression of VEGF,and shorten the time of wound healing.

关 键 词：压力性损伤 紫草油 化瘀生肌方 炎性因子 血管内皮生长因子 压疮愈合程度 中医症候积分 

分 类 号：R751[医药卫生—皮肤病学与性病学]