C4二醇的发酵生产及其化学催化升级为高价值化学品的研究进展  

Recent advances in fermentative production of C4 diols and their chemo‐catalytic upgrading to high‐value chemicals

作　　者：Abhishek R.Varma Bhushan S.Shrirame Sunil K.Maity Deepti Agrawal Naglis Malys Leonardo Rios-Solis Gopalakrishnan Kumar Vinod Kumar Abhishek R.Varma;Bhushan S.Shrirame;Sunil K.Maity;Deepti Agrawal;Naglis Malys;Leonardo Rios-Solis;Gopalakrishnan Kumar;Vinod Kumar(Department of Chemical Engineering,Indian Institute of Technology Hyderabad,Kandi,Sangareddy 502284,Telangana,India;Biochemistry and Biotechnology Area,Material Resource Efficiency Division,CSIR‐Indian Institute of Petroleum,Dehradun 248005,Uttarakhand,India;Department of Organic Chemistry,Faculty of Chemical Technology,Kaunas University of Technology,RadvilėnųStreet 19,LT‐50254 Kaunas,Lithuania;Department of Biochemical Engineering,University College London,Gower Street,London WC1E 6BT,United Kingdom;School of Civil and Environmental Engineering,Yonsei University,Seoul 03722,Republic of Korea;School of Water,Energy and Environment,Cranfield University,Cranfield MK430AL,United Kingdom;Department of Bioscience and Bioengineering,Indian Institute of Technology Roorkee,Uttarakhand 247667,India;C‐Source Renewables Limited,Summit House,4‐5 Mitchell Street,Edinburgh,EH67BD,United Kingdom)

机构地区：[1]印度海得拉巴理工学院化学工程系,特伦甘纳桑加雷迪,印度 [2]CSIR-印度石油研究所材料资源效率处,生物化学和生物技术区,北阿坎德邦德拉敦,印度 [3]考纳斯理工大学化学技术学院有机化学系,考纳斯,立陶宛 [4]伦敦大学学院生物化学工程系,伦敦,英国 [5]延世大学土木与环境工程学院,首尔,韩国 [6]克兰菲尔德大学水能源与环境学院,克兰菲尔德,英国 [7]印度鲁尔基理工学院生物科学与生物工程系,北阿坎德邦,印度 [8]碳源可再生能源有限公司,爱丁堡,英国

出　　处：《Chinese Journal of Catalysis》2023年第9期99-126,共28页催化学报（英文）

摘　　要：化石资源的过度消耗导致能源和环境污染问题,迫切需要科研人员开发出可持续、低能耗、绿色低碳的化学品生产技术.生物技术利用“细胞工厂”,以生物质等可再生资料为原料生产基础化学品,是以化石资源为原料的合成方法的潜在替代方案.然而,利用生物技术生产全系列石化产品存在其自身的局限性,因此,人们对集成/混合方法越来越感兴趣,该方法先采用生物技术对生物质升级,再通过化学催化的途径使其转化为含有活性官能团的产物.本文主要综述了C4二醇的三种重要结构异构体,2,3-、1,3-和1,4-丁二醇的生物生产方法,目前这些异构体主要通过石化路线生产,全球市场需求不断增长.首先,从集成方法的原理出发,总结了上述二醇的生物法生产现状,包括底物、微生物、发酵技术和代谢/途径工程和发酵技术.然后,全面总结了C4二醇催化升级以生产系列产物的最新研究进展,讨论了催化剂中不同活性位点对催化活性、产物选择性和催化剂稳定性的影响.此外,给出了集成方法的具体实例,解决开发C4二醇生物生产工艺的相关挑战,强调通过直接催化转化方法对其升级所存在的困难.最后,对C4二醇的发酵生产及其化学催化升级为高价值化学品的相关研究进行总结,对未来发展进行展望,并指出将生物催化和化学催化方法相结合对于拓宽生物质升级转化产物范围具有重要作用.The current era is witnessing the transition from a fossil-dominated economy towards sustainable and low-carbon green manufacturing technologies at economical prices with reduced energy usage.The biological production of chemical building blocks from biomass using cell factories is a potential alternative to fossil-based synthesis.However,microbes have their own limitations in generating the whole spectrum of petrochemical products.Therefore,there is a growing interest in an integrated/hybrid approach where products containing active functional groups obtained by biological upgrading of biomass are converted via chemo-catalytic routes.The present review focuses on the biological production of three important structural isomers of C4 diols,2,3-,1,3-,and 1,4-butanediol,which are currently manufactured by petrochemical route to meet the soaring global market demand.The review starts with justifications for the integrated approach and summarizes the current status of the biological production of these diols,including the substrates,microorganisms,fermentation technology and metabolic/pathway engineering.This is followed by a comprehensive review of recent advances in catalytic upgrading of C4 diols to generate a range of products.The roles of various active sites in the catalyst on catalytic activity,product selectivity,and catalyst stability are discussed.The review also covers examples of integrated approaches,addresses challenges associated with developing end-to-end processes for bio-based production of C4 diols,and underlines existing limitations for their upgrading via direct catalytic conversion.Finally,the concluding remarks and prospects emphasise the need for an integrated biocatalytic and chemo-catalytic approach to broaden the spectrum of products from biomass.

关 键 词：丁二醇 发酵 代谢工程 多相催化 1 3-丁二烯 3-丁烯-1-醇 3-丁烯-2-醇 甲乙酮 

分 类 号：F42[经济管理—产业经济]