膜性肾病患者合并新型冠状病毒感染临床特征及短期预后分析  

Clinical features and short-term outcomes of patients with membranous nephropathy complicated with COVID-19

作　　者：郭凯琦 王伟[2] 李小伟[1] Guo Kai-qi;Wang Wei;Li Xiao-wei(Department of Nephrology,Affiliated Fuyang People’s Hospital,Anhui Medical University,Fuyang 236000,China;Department of Laboratory Medicine,Affiliated Fuyang People’s Hospital,Anhui Medi-cal University,Fuyang 236000,China)

机构地区：[1]安徽医科大学附属阜阳人民医院肾内科,阜阳236000 [2]安徽医科大学附属阜阳人民医院检验科,阜阳236000

出　　处：《临床肾脏病杂志》2023年第11期910-915,共6页Journal Of Clinical Nephrology

基　　金：安徽省重点研究与开发计划(2022e07020057);蚌埠医学院自然科学重点项目(BYKT2019228ZD)。

摘　　要：目的 评估新型冠状病毒感染对膜性肾病(membranous nephropathy, MN)患者的影响。方法 回顾性分析安徽医科大学附属阜阳人民医院2022年12月15日至2023年1月6日感染新型冠状病毒的61例MN患者的人口学、临床表现、治疗转归及预后等资料。结果 (1)61例患者中男性40例(65.6%),年龄(51.7±12.8)岁,31例(50.8%)MN达到临床缓解,51例(83.6%)接种过2剂或以上新冠疫苗。(2)感染新型冠状病毒后MN患者可出现多系统临床症状,前3位分别是发热(78.7%)、咳嗽咳痰(52.5%)、乏力(44.3%)。仅出现1种症状的患者12例(19.7%),3种及以上症状患者41例(67.2%)。依据新型冠状病毒感染诊疗方案(试行第十版),轻型58例(95.1%),中型3例(4.9%)。(3)MN患者合并新型冠状病毒感染以对症治疗为主,在新型冠状病毒感染后1个月内,多数患者病情稳定,仅1例复发,1例患者并发急性肾损伤。结论 MN合并新型冠状病毒感染患者的临床症状较轻,短期预后较好。Objective To evaluate the effect of COVID-19 in patients with membranous nephropathy(MN).Methods From December 15,2022 to January 6,2023,retrospective review was per-formed for personal demographics,clinical symptoms and treatment outcomes of 61 MN patients with COVID-19.Results There were 40 males and 21 females with a mean age of(51.7±12.8)year.And 31 cases(50.8%)achieved clinical remission and 51(83.60%)had received two or more doses of COVID-19 vaccine.After an infection of COVID-19,MN patients presented multi-system clinical symptoms.Top three were fever(78.7%),cough&sputum(52.5%)and fatigue(44.3%).Twelve patients(19.7%)had on-ly one symptom and 41 cases(67.2%)had three or more symptoms.According to the Diagnostic and Ther-apeutic Protocol for Novel Coronavirus Infection(Trial Edition X),58 cases(95.1%)were mild and 3(4.9%)medium.MN patients with COVID-19 were treated mostly symptomatically.Within 1 month after COVID-19,most patients stabilized.Only 1 case relapsed and another developed acute kidney injury.Conclusions MN patients with COVID-19 have milder clinical symptoms and better short-term out-comes.

关 键 词：新型冠状病毒 肾小球肾炎 膜性 临床特征 预后 

分 类 号：R692[医药卫生—泌尿科学] R563.1[医药卫生—外科学]