精神科无指征使用抗菌药物现状及干预策略分析  

Status Quo of Unindicated Use of Antibiotics in Departments of Psychiatry and Intervention Strategies

作　　者：李焕芬[1] 王金宝[1] 张建宏[2] 王新法[2] 孙玉玺[2] LI Huan-fen;WANG Jin-bao;ZHANG Jian-hong;WANG Xin-fa;SUN Yu-xi(Department of Pharmacy,the Second Affiliated Hospital of Xinxiang Medical University,Xinxiang 453002,China;Department of Psychiatry,the Second Affiliated Hospital of Xinxiang Medical University,Xinxiang 453002,China)

机构地区：[1]新乡医学院第二附属医院药学部,新乡453002 [2]新乡医学院第二附属医院精神科,新乡453002

出　　处：《中国合理用药探索》2023年第11期74-78,共5页Chinese Journal of Rational Drug Use

摘　　要：目的:对精神科住院患者无指征使用抗菌药物现状进行分析,为降低精神科住院患者抗菌药物使用率提供参考。方法:选取某院3个精神科室2022年1~12月的出院患者为研究对象,回顾性分析精神科无指征使用抗菌药物的情况并提出用药干预措施,比较干预前后3个精神科的抗菌药物使用率、抗菌药物无指征使用情况以及干预前后呼吸道感染患者病情的转归情况。结果:干预前,使用抗菌药物患者的主要感染性疾病为肺部感染和上呼吸道感染,且均存在无指征使用的问题。经过干预,抗菌药物无指征使用率从31.78%下降至10.34%(P=0.030),抗菌药物使用率从20.79%降低至8.31%(P<0.01)。无指征用药的呼吸道感染患者中,使用抗菌药物者和及时进行干预后不使用抗菌药物者的痊愈率比较无统计学差异(P>0.05)。结论:该院精神科存在无指征使用抗菌药物现象。临床药师进行医嘱点评并采取相关干预措施可明显降低精神科住院患者的抗菌药物使用率。Objective:To analyze the current situation of unindicated use of antibiotics in inpatients in departments of psychiatry,so as to provide reference for reducing the use of antibiotics in those patients.Methods:We retrospectively analyzed the discharge records dated from January to December 2022 collected from three psychiatric departments of a hospital to examine the unindicated use of antibiotics in the department of psychiatry and proposed interventions for use of such drugs.We also compared the use of antibiotics and the unindicated use of antibiotics in the three psychiatric departments before and after intervention,as well as the outcomes of the patients with respiratory infections after intervention.Results:Before intervention,the patients treated with antibiotics mainly had lung infections and upper respiratory tract infections,and unindicated use of antibiotics was a common problem in these patients.After intervention,the unindicated use of antibiotics decreased from 31.78%to 10.34%(P=0.030)among the target inpatients,and the use of antibiotics decreased from 20.79%to 8.31%(P<0.01).There was no statistically significant difference in the rate of healing among patients with respiratory tract infections who were on antimicrobials without indicated medications compared to those who were not on antimicrobials after timely interventions(P>0.05).Conclusion:Unindicated use of antibiotics is a common phenomenon in departments of psychiatry.Clinical pharmacists can play an important role in reducing the use of antibiotics for inpatients in the department of psychiatry by reviewing the doctor's medical advice and taking relevant interventions.

关 键 词：抗菌药物 精神科 无指征用药 现状 干预策略 

分 类 号：R969.3[医药卫生—药理学]