纳美芬用于急性一氧化碳中毒抢救效果观察  

Application Effect of Namefene in the Rescue of Acute Carbon Monoxide Poisoning

作　　者：黄雪玲 侯成民 刘明 HUANG Xueling;HOU Chengmin;LIU Ming(Xinjiang Uygur Autonomous Region Maternal and Child Health Hospital,Urumqi,Xinjiang,China 830000)

机构地区：[1]新疆维吾尔自治区妇幼保健院,新疆乌鲁木齐830000

出　　处：《中国药业》2023年第S01期43-45,共3页China Pharmaceuticals

摘　　要：目的探讨纳美芬在急性一氧化碳中毒抢救中的应用效果。方法选取医院2018年8月至2019年8月收治的急性一氧化碳中毒患者60例,随机分为对照组和观察组,各30例。对照组行常规支持治疗,观察组在对照组基础上联合纳美芬治疗,比较患者的治疗效果。结果观察组的救治总有效率为93.33%,显著高于对照组的70.00%(P<0.05);观察组的不良反应发生率为6.67%,显著低于对照组的30.00%(P<0.05)。对照组和观察组在INR国际标准化比率(即凝血指标)四指标的数据分别为(13.9±0.7)s和(13.1±0.5)s、(18.1±1.9)s和(15.9±1.8)s、(38.1±1.4)s和(8.9±1.8)s、(1.8±0.6)g/L和(2.6±0.3)g/L,差异显著(P<0.05)。治疗后,观察组患者的蒙特利尔认知评估量表(MoCA)和简易智力状态检查量表(MMSE)评分均显示高于观察组(P<0.05)。观察组患者的并发症发生率显示低于对照组(P<0.05)。结论纳美芬用于急性一氧化碳中毒的救治效果确切,安全性较高。Objective To investigate the application effect of Namefene in the rescue of acute carbon monoxide poisoning.Methods Sixty patients with acute carbon monoxide poisoning admitted to the hospital from August 2018 to August 2019 were selected and randomly divided into the control group and the observation group,with 30 cases in each group.The control group received routine supportive treatment,while the observation group received combination therapy with Namefene on the basis of the control group.The treatment effects of patients were compared.Results The total effective rate in the observation group was 93.33%,which was significantly higher than 70.00%in the control group(P<0.05).The incidence of adverse reactions in the observation group was 6.67%,which was significantly lower than 30.00%in the control group(P<005).The data for the four indicators of INR international standardized ratio(i.e.coagulation index)in the control group and observation group were(13.9±0.7)s and(13.1±0.5)s,(18.1±1.9)s and(15.9±1.8)s,(38.1±1.4)s and(8.9±1.8)s,(1.8±0.6)g/L and(2.6±0.3)g/L,with significant differences(P<0.05).After treatment,the Montreal Cognitive Rating Scale(MoCA)and Mini Mental State Examination(MMSE)scores in the observation group were higher than those in the observation group(P<0.05).The incidence of complications in the observation group was lower than that in the control group(P<0.05).Conclusion Namifen has a definite therapeutic effect and high safety in the treatment of acute carbon monoxide poisoning.

关 键 词：纳美芬 急性一氧化碳中毒 临床疗效 

分 类 号：R969.4[医药卫生—药理学] R971[医药卫生—药学]