依托咪酯靶控输注用于妇科腹腔镜手术麻醉临床评价  

Clinical Evaluation of Etomidate Target-Controlled Infusion for Anesthesia in Gynecologic Laparoscopic Surgery

作　　者：许开敢 王运洁 黄胜[1] 陈世鸿[1] XU Kaigan;WANG Yunjie;HUANG Sheng;CHEN Shihong(Department of Anesthesiology,Wuzhou Red Cross Hospital,Wuzhou,Guangxi,China 543002)

机构地区：[1]广西壮族自治区梧州市红十字会医院麻醉科,广西梧州543002

出　　处：《中国药业》2023年第S01期87-90,共4页China Pharmaceuticals

摘　　要：目的分析依托咪酯靶控输注用于妇科腹腔镜手术麻醉的效果。方法选取医院妇科2021年2月至2022年2月接受腹腔镜手术的患者84例,按麻醉方式的不同分为甲组和乙组,各42例。两组均静脉注射阿托品0.5 mg,咪达唑仑0.05 mg/kg,芬太尼2~3μg/kg,罗库溴铵0.5 mg/kg麻醉,在此基础上,甲组加用异丙酚1 mg/kg静脉注射,并维持异丙酚血浆靶浓度在2~4μg/kg;乙组靶控输注依托咪酯0.2~0.3 mg/kg,并维持依托咪酯血浆靶浓度在0.30~0.32μg/kg。手术结束前5 min停药。结果乙组用药后1 min(T_(1))、插管前(T_(2))、插管即刻(T_(3))、插管后3 min(T_(4))时的心率、收缩压、舒张压显著低于甲组(P<0.05);乙组的睁眼时间、拔管时间、回答时间均明显短于甲组(P<0.05)。结论依托咪酯靶控输注用于妇科腹腔镜手术麻醉起效快,有利于手术顺利进行,且术后恢复时间较短。Objective To analyze the effect of target-controlled infusion of etomidate on anesthesia for gynecologic laparoscopic surgery.Methods Eighty-four patients who underwent laparoscopic surgery in the Department of Gynecology of the hospital from February 2021 to February 2022 were selected and divided into group A and group B according to the different anesthesia methods,with 42 cases in each group.Patients in both groups were anesthetized with intravenous of atropine(0.5 mg),midazolam(0.05 mg/kg),fentanyl(2-3μg/kg),and rocuronium bromide(0.5 mg/kg,)based on this,in group A,isoproterenol(1 mg/kg)was injected intravenously,and the plasma target concentration of isoproterenol was maintained at 2-4μg/kg;in group B,etomidate(0.2-0.3 mg/kg)was injected in a target-controlled manner,and the plasma target concentration of etomidate was maintained at 0.30-0.32μg/kg,and the drug was discontinued 5 min before the end of the operation.Results The heart rate,systolic blood pressure,and diastolic blood pressure in group B were significantly lower than those in group A at 1 min after drug administration(T_(1)),before intubation(T_(2)),immediately after intubation(T_(3)),and at 3 min after intubation(T_(4))(P<0.05);the time for opening the eyes,pulling out the tube,and answering the question in group B were significantly shorter than those in group A(P<0.05).Conclusion Etomidate target-controlled infusion for gynecological laparoscopic surgery anesthesia has a rapid onset of effect,it is conducive to the smooth progress of surgery,and has a shorter postoperative recovery time.

关 键 词：妇科 腹腔镜手术 靶控输注 依托咪酯 麻醉 

分 类 号：R969.4[医药卫生—药理学] R971.2[医药卫生—药学]