对传统中药汤剂用于铜绿假单胞菌感染文献特征分析  

Literature Characteristics of Application of Traditional Chinese Medicine Decoction for Pseudomonas Aeruginosa Infection

作　　者：李爱君[1] 王君伟[2] 冯硕[3] 熊露[2] LI Aijun;WANG Junwei;FENG Shuo;XIONG Lu(Dept.of Pharmacy,South Campus of Guang’anmen Hospital of China Academy of Chinese Medical Sciences,Beijing 102600,China;Dept.of Oncology,Guang’anmen Hospital of China Academy of Chinese Medical Sciences,Beijing 100053,China;Centre for Evidence-based Medicine,South Campus of Guang’anmen Hospital of China Academy of Chinese Medical Sciences,Beijing 102600,China)

机构地区：[1]中国中医科学院广安门医院南区药剂科,北京102600 [2]中国中医科学院广安门医院肿瘤科,北京100053 [3]中国中医科学院广安门医院南区循证医学中心,北京102600

出　　处：《中国医院用药评价与分析》2023年第11期1377-1380,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：中国中医科学院广安门医院南区第三批本部专家(熊露)学术经验传承项目;广安门医院南区所级项目(No.Y2019-17;No.Y2021-18)。

摘　　要：目的:基于文献分析,探讨传统中药汤剂在抗铜绿假单胞菌感染方面的特征,为临床应用中药汤剂抗铜绿假单胞菌感染提供参考。方法:检索中国知网、维普数据库和万方数据库,筛选传统中药汤剂应用于铜绿假单胞菌感染方面的临床、实验研究相关文献,检索时间范围为建库至2022年11月。对纳入文献的研究方向、治则、组方、给药途径等进行分析。结果:共纳入34篇文献,其中24篇涉及内科感染相关研究,10篇涉及外科及皮科感染;研究方向主要为作用机制研究、体外抑菌能力研究和临床疗效研究;中医治则主要为“祛邪”;文献涉及中药77种;16篇临床研究文献涉及病原学,研究时间平均为12.5 d。结论:传统中药汤剂抗铜绿假单胞菌感染是有效的,通过影响自身免疫和作用于细胞膜等多个机制发挥作用,并减少耐药性产生。但部分文献质量不高,研究结论的严谨性需要进一步提升,存在不按照中医辨证规律用药、忽略中医证型变化且缺乏中医证型、仅通过痰培养来判断铜绿假单胞菌感染等问题,需要更多科学严谨的方证对应研究、疗效机制研究来进一步明确传统中药汤剂在铜绿假单胞菌感染等方面的抗感染作用。传统中药汤剂减少铜绿假单胞菌定植方面还未发现相关研究。OBJECTIVE:To probe into the characteristics of the application of traditional Chinese medicine decoction for the anti-infection of Pseudomonas aeruginosa based on literature analysis,so as to provide references for clinical application of Chinese herbal decoction for the anti-infection of P.aeruginosa.METHODS:Clinical and experimental studies of the application of Traditional Chinese medicine decoction for P.aeruginosa infection were screened out by retrieving CNKI,VIP and Wanfang Data from base-building to Nov.2022.The enrolled studies were analyzed in terms of research direction,therapeutic principle,formula,administration route,etc.RESULTS:A total of 34 studies were enrolled,of which 24 were related to internal medical infections and 10 studies were related to surgical and dermatological infections;the research direction was mainly on the mechanism of action,in vitro bacterial inhibition and clinical efficacy;the main therapeutic principle of traditional Chinese medicine was to“pathogens eliminating”;77 categories of traditional Chinese medicines were involved;16 clinical studies were related to pathogenetics,and the average research duration was 12.5 d.CONCLUSIONS:Traditional Chinese medicine decoction is effective against P.aeruginosa infections through multiple mechanisms,including influencing autoimmunity,acting on cell membranes and reducing the emergence of drug resistance.However,some of the literature is of low quality,the rigor of the research conclusions needs to be further improved,there are problems such as not using drugs in accordance with the rules of Chinese medicine identification,ignoring the changes of traditional Chinese medicine syndrome and lacking of traditional Chinese medicine syndrome,and determining P.aeruginosa infection only by sputum culture,etc.More scientific and rigorous studies with correspondence between formula and evidence and the mechanism of therapeutic efficacy are needed to further define the anti-infective effects of traditional Chinese medicine decoction against P

关 键 词：中药汤剂 铜绿假单胞菌 文献特征分析 

分 类 号：R932[医药卫生—生药学]