他克莫司致神经系统不良反应文献分析  

Literature Analysis of Nervous System Adverse Drug Reactions Induced by Tacrolimus

作　　者：陈慧颖 陈冠儒 彭寅 邓芳 CHEN Huiying;CHEN Guanru;PENG Yin;DENG Fang(Dept.of Pharmacy,Anhui Children’s Hospital,Hefei 233000,China;Dept.of Nephrology,Anhui Children’s Hospital,Hefei 233000,China)

机构地区：[1]安徽省儿童医院药剂科,合肥233000 [2]安徽省儿童医院肾内科,合肥233000

出　　处：《中国医院用药评价与分析》2023年第11期1396-1399,共4页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:了解他克莫司致神经系统不良反应的特点,为临床安全用药提供参考。方法:以“他克莫司不良反应”“他克莫司癫痫”“他克莫司后部脑白质病”“他克莫司神经系统”“TAC ADR”“TAC epilepsy”“TAC nervous system”和“tacrolimus posterior reversible encephalopathy syndrome”为检索词,检索2011年5月至2021年5月中国知网、维普数据库、万方数据库及PubMed等数据库中收载的他克莫司致神经系统不良反应的个案报道,并进行分析。结果:共筛选出有效个案报道37篇,涉及45例患者,其中男性患者25例,女性患者20例,≤50岁者33例(占73.33%)。他克莫司致神经系统不良反应多发生在用药后1个月内,有26例(占57.78%)。发生神经系统不良反应后,27例患者(占60.00%)立即停用他克莫司。对症治疗处理后,1例患者死亡,4例患者临床症状未得到改善,40例患者好转。结论:他克莫司致神经系统不良反应在临床中常见,可发生于用药后数日或数十年,用药过程中需进行血药浓度监测,以便及时发现和处理相关神经系统症状,保障用药安全。OBJECTIVE:To investigate the characteristics of nervous system adverse drug reactions induced by tacrolimus,so as to provide reference for clinical rational drug use.METHODS:“Tacrolimus adverse drug reactions”“tacrolimus epilepsy”“tacrolimus posterior leukoencephalopathy”“tacrolimus neurological”“TAC ADR”“TAC epilepsy”“TAC nervous system”and“tacrolimus posterior reversible encephalopathy syndrome”were used as the search terms to retrieve the databases of CNKI,VIP,Wanfang Data and PubMed from May 2011 to May 2021 for the following case reports of nervous system adverse drug reactions induced by tacrolimus.RESULTS:A total of 37 valid case reports were screened out,including 45 patients,with 25 males and 20 females,and 33 cases≤50 years old(73.33%).Most of the adverse drug reactions induced by tacrolimus occurred within 1 month after treatment,with 26 cases(57.78%).After the occurrence of nervous system adverse drug reactions,tacrolimus was immediately discontinued in 27 patients(60.00%).After symptomatic treatment,1 patient died,clinical symptoms of 4 patients did not improve,and clinical symptoms were improved in 40 patients.CONCLUSIONS:Nervous system adverse drug reactions induced by tacrolimus are common in clinical practice and can occur several days or decades after medication.Blood concentration monitoring is required during medication to detect and deal with related nervous system symptoms in time to ensure the safety of medication.

关 键 词：他克莫司 神经系统 不良反应 

分 类 号：R978.1[医药卫生—药品] R979.5[医药卫生—药学]