血小板内皮聚集受体-1基因多态性与间歇性血液透析患者血管通路感染的相关性  

Correlation between platelet endothelial aggregation receptor-1 gene polymorphisms and vascular access infections in intermittent hemodialysis patients

作　　者：闫晓辉[1] 赵娟茹[2] 梁衍[1] YAN Xiaohui;ZHAO Juanru;LIANG Yan(Department of Nephrology,Shaanxi Provincial People′s Hospital,Xi′an 710065,Shaanxi Province,China;Department of Geriatrics,Shaanxi Provincial People′s Hospital,Xi′an 710065,Shaanxi Province,China)

机构地区：[1]陕西省人民医院肾内科,陕西西安710065 [2]陕西省人民医院老年病科,陕西西安710065

出　　处：《新乡医学院学报》2023年第12期1151-1155,共5页Journal of Xinxiang Medical University

摘　　要：目的探讨血小板内皮聚集受体-1(PEAR1)基因多态性与间歇性血液透析(IHD)患者血管通路感染的相关性。方法选择2019年1月至2022年1月于陕西省人民医院收治的105例接受IHD治疗的患者为观察组,另选取同期入院体检的健康者50例为对照组,采用荧光定量聚合酶链式反应法检测2组受试者PEAR1基因多态性。另外,观察组患者进行影像学、血清学、病原学等检查,根据是否发生血管通路感染将患者分为感染组和未感染组,比较2组患者的临床资料,采用单因素分析和多因素logsitic回归分析PEAR1基因多态性与IHD患者血管通路感染的相关性。结果观察组和对照组受试者PEAR1基因位点均有G和A 2个等位基因,检出3种基因型,包括野生型(GG)、突变杂合型(GA)、突变纯合型(AA)。观察组患者的GG基因型频率、G等位基因型频率均高于对照组(P<0.05);观察组和对照组受试者基因位点等位基因频率均符合哈迪-温伯格平衡(P>0.05);单因素分析显示,感染组和未感染组患者性别比例、体温、体质量指数、血压、三酰甘油、总胆固醇、低密度脂蛋白、高密度脂蛋白、GA和AA基因型频率及高血脂史、抽烟史、饮酒史占比比较差异无统计学意义(P>0.05);未感染组患者年龄、透析时间≥3 a占比、透析频率1周≥3次占比、PEAR1 GG基因型频率、PEAR1 G等位基因频率、肌钙蛋白T水平、白细胞水平、血小板计数、血细胞比容、降钙素原水平、中性粒细胞/淋巴细胞比值、血小板/淋巴细胞比值、高血压史占比、糖尿病史占比均低于感染组,PEAR1 A等位基因频率均高于感染组(P<0.05)。Logistic回归分析显示,透析时间长、年龄大及高透析频率、高中性粒细胞/淋巴细胞比值、高血小板/淋巴细胞比值和PEAR1 G等位基因是影响IHD患者发生血管通路感染的危险因素(P<0.05)。结论IHD患者存在PEAR1基因型表达异常,其中PEAR1基因型为GG的�Objective To explore the correlation between platelet endothelial aggregation receptor-1(PEAR1)gene polymorphisms and vascular access infections in intermittent hemodialysis(IHD)patients.Methods Totally 105 patients who received IHD treatment in Shaanxi Provincial People′s Hospital from January 2019 to January 2022 were selected as the observation group,and 50 healthy people who were admitted to the hospital for physical examination at the same period were selected as the control group,and PEAR1 gene polymorphisms of the subjects in the two groups were tested by polymerase chain reaction.In addition,the patients in the observation group underwent imaging,serology,and pathogenesis,and they were divided into infected group and uninfected group according to whether vascular access infections occurred,and the clinical data of patients between the two groups were compared,and the correlation between PEAR1 gene polymorphisms and vascular access infections in IHD patients was analyzed by using univariate and multifactorial logsitic regression.Results There were two alleles G and A at the PEAR1 gene locus of patients in the observation group and control group;and three genotypes were detected,including wild-type(GG),mutant heterozygous(GA),and mutant pure(AA).The frequency of the GG genotype and the frequency of the G allele genotype of the patients in the observation group were higher than those in the control group(P<0.05);the allele frequencies of the gene loci of the subjects in the observation group and the control group were in accordance with the Hardy-Weinberg equilibrium(P>0.05).Univariate analysis showed that there was no statistically significant difference in the sex ratio,body temperature,body mass index,blood pressure,triglyceride,total cholesterol,low-density lipoprotein,high-density lipoprotein,frequency of the GA and AA genotypes,percentage of history of hyperlipidemia,percentage of history of cigarette smoking,and percentage of history of alcohol consumption of patients between the infected group and

关 键 词：血小板内皮聚集受体-1 基因多态性 间歇性血液透析 血管通路感染 

分 类 号：R446[医药卫生—诊断学]