脂质代谢在主动脉中膜退行性变中的研究进展  

Research Progress of Lipid Metabolism in Aortic Medial Degeneration

作　　者：王可鑫 胡小平[1] 任宗力[1] WANG Kexin;HU Xiaoping;REN Zongli(Department of Cardiovascular Surgery,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院心血管外科,武汉430060

出　　处：《医学综述》2023年第21期4409-4414,共6页Medical Recapitulate

基　　金：国家自然科学基金(82100423)。

摘　　要：主动脉夹层(AD)和主动脉瘤是心血管外科常见的大血管疾病,病情凶险,致死率和致残率较高,严重危害人体健康。目前两者的确切发病机制尚未明确,但共同的病理基础是主动脉中膜退行性变(AMD)。脂质代谢是人体重要的生理活动,其可通过调控血管炎症、平滑肌细胞表型转化、细胞外基质降解、氧化应激等机制参与AMD。对于脂质代谢参与AMD的机制研究,可为AD与主动脉瘤的临床诊治及基础研究提供新思路。Aortic dissection(AD)and aortic aneurysm are common macrovascular diseases in cardiovascular surgery.They seriously endanger human health with high mortality and disability rates.The exact pathogenesis of both is currently not clear,but the common pathological basis is aortic medial degeneration(AMD).Lipid metabolism is an important physiological activity of human body,which participate in AMD by regulating vascular inflammation,smooth muscle cell phenotype transformation,extracellular matrix degradation,oxidative stress and other mechanisms.The study on the mechanism of lipid metabolism involved in AMD will provide new ideas and directions for the clinical diagnosis and treatment of AD and aortic aneurysm.

关 键 词：主动脉中膜退行性变 血管炎症 脂质代谢 表型转化 氧化应激 

分 类 号：R654[医药卫生—外科学]