lncRNA调控滋养层细胞功能与复发性流产关系的研究进展  

Research Progress in Relationship between LncRNA Regulation of Trophoblast Cell Function and Recurrent Spontaneous Abortion

作　　者：钱艳平 姜丽娟 陈茁 QIAN Yanping;JIANG Lijuan;CHEN Zhuo(Department of Gynecology,the First Affiliated Hospital of Yunnan University of Chinese Medicine/Yunnan Provincial Hospital of Traditional Chinese Medicine,Kunming 650021,China)

机构地区：[1]云南中医药大学第一附属医院云南省中医医院妇科,昆明650021

出　　处：《医学综述》2023年第21期4450-4457,共8页Medical Recapitulate

基　　金：国家自然科学基金(82060882);云南省科技厅科技计划项目(202102AA100008);云南省“万人计划”名医专项人才项目(云卫人发〔2019〕1号);云南中医药大学校院联合基金项目(YXLH202105)。

摘　　要：复发性流产(RSA)是一种严重的妊娠并发症,其临床发病率不断增加,治疗方法多样,但疗效欠佳。RSA的病因病机错综复杂,遗传学、免疫学和细胞生物学的发展已经确定了长链非编码RNA(lncRNA)在RSA的发生中扮演重要角色。lncRNA可以通过调节胎盘滋养层细胞的增殖、迁移、凋亡和侵袭,参与RSA的发生和发展。不同的lncRNA通过不同的信号通路和作用靶点对RSA产生不同的抑制或促进作用,但具体发病机制仍需进一步探讨。未来深入研究lncRNA与妊娠相关疾病的关系,将为RSA的诊断、预测生物标志物以及寻找治疗靶标提供新思路。Recurrent spontaneous abortion(RSA)is a serious pregnancy complication.Its clinical incidence rate is increasing,and the treatment methods are diverse,but the effect is poor.The various causes of RSA are complicated,and the development of genetics,immunology,and cell biology have identified important roles of long non-coding RNA(lncRNA)in the occurrence and progress of RSA.LncRNA can participate in the occurrence of RSA by affecting the proliferation,migration,apoptosis and invasion of placental trophoblast cells.Different lncRNA have different inhibition or promotion effects on RSA through different signal pathways and action targets,but the specific pathogenesis remains to be further investigated.In the future,in-depth research on the relationship between lncRNA and pregnancy related diseases will provide new ideas for the diagnosis,predictive biomarkers,and search for therapeutic targets of RSA.

关 键 词：复发性流产 长链非编码RNA 胎盘滋养层细胞 

分 类 号：R714.21[医药卫生—妇产科学]