骨质疏松症与高尿酸血症的共同发病机制及治疗进展  

Co-pathogenesis and Treatment Progress of Osteoporosis and Hyperuricemia

作　　者：李玥涟 赵凌霞[1] 薛雪花[1] LI Yuelian;ZHAO Lingxia;XUE Xuehua(Department of Endocrinology,the Third Hospital of Shanxi Medical University/Shanxi Bethune Hospital/Shanxi Academy of Medical Sciences/Tongji Shanxi Hospital,Taiyuan 030032,China)

机构地区：[1]山西医科大学第三医院山西白求恩医院山西医学科学院同济山西医院内分泌科,太原030032

出　　处：《医学综述》2023年第21期4614-4618,4623,共6页Medical Recapitulate

基　　金：山西省卫生计生委科研课题(2018GW26)。

摘　　要：随着近年人口老龄化的进程,骨质疏松症已成为世界常见慢性病,同时高尿酸血症发病率也随着人们生活、饮食习惯的变化而逐年升高。尿酸作为内源性抗氧化剂,其在血中含量的升高可产生氧化应激反应及炎症因子,抑制维生素D活化和钙吸收,使骨代谢失衡而引发骨质疏松。补充含有多酚类和硫化物的水果及蔬菜可保证维生素D制剂和钙剂的摄入,能够有效降低高尿酸水平,抑制骨吸收,预防骨质疏松。未来应进一步深入研究膳食补充对高尿酸血症及骨质疏松症的作用,以为高尿酸血症和骨质疏松症的整体防治提供新思路。In recent years,with the aging of the population,osteoporosis has become a common chronic disease in the world.Meanwhile,with the change of people′s living and eating habits,the incidence of hyperuricemia has also increased year by year.As an endogenous antioxidant,uric acid can produce oxidative stress reactions and inflammatory factors,inhibit vitamin D activation and calcium absorption when its content in the blood increases,leading to imbalance in bone metabolism and osteoporosis.By supplementing fruits and vegetables containing polyphenols and sulfides,while ensuring the intake of vitamin D preparations and calcium agents,it can safely and effectively reduce high uric acid levels,inhibit bone absorption,and prevent osteoporosis.In the future,further in-depth research should be conducted on the effects of dietary supplementation on hyperuricemia and osteoporosis,providing new ideas for the overall prevention and treatment of hyperuricemia and osteoporosis.

关 键 词：高尿酸血症 骨质疏松症 炎症反应 氧化应激 维生素D 钙 

分 类 号：R589.5[医药卫生—内分泌]