小窝蛋白3在糖尿病心肌缺血再灌注损伤中的研究进展  

Research Progress of Caveolin-3 in Myocardial Ischemia-Reperfusion Injury in Diabetes

作　　者：张岳甫 刘宇彤 郭俊凡 文昕郁 雷少青[1] ZHANG Yuefu;LIU Yutong;GUO Junfan;WEN Xinyu;LEI Shaoqing(Department of Anaesthesiology,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院麻醉科,武汉430060

出　　处：《医学综述》2023年第21期4687-4692,共6页Medical Recapitulate

基　　金：国家自然科学基金(81772049)。

摘　　要：心肌缺血再灌注损伤(MIRI)是缺血心肌恢复血液灌注后出现的严重并发症。糖尿病患者较非糖尿病患者更易发生MIRI,且损伤程度更为严重,这也是糖尿病患者围手术期死亡的首要原因,但其具体机制目前尚未阐明。小窝蛋白3(Cav-3)是构成心肌细胞小窝结构的核心蛋白,参与调控促细胞生存信号通路转导、糖脂代谢、氧化应激、线粒体稳态、内质网应激及细胞自噬等过程,在MIRI中起关键保护作用。心肌Cav-3表达降低是糖尿病MIRI敏感性和易损性增加的重要原因,深入研究Cav-3在糖尿病MIRI中的具体机制有望为防治糖尿病MIRI提供新靶点、新策略。Myocardial ischemia-reperfusion injury(MIRI)is a serious complication of ischemic myocardium after blood reperfusion.Patients with diabetes are more susceptible to MIRI,and the injury degree is more severe,which is the primary cause of perioperative death in diabetes,but the specific mechanism is not yet clear.Caveolin-3(Cav-3)is the core protein of cardiomyocyte caveolae,and is involved in regulation of pro-cell survival signaling pathway transduction,glycolipid metabolism,oxidative stress,mitochondrial homeostasis,endoplasmic reticulum stress and autophagy,playing a key role in protection of MIRI.Decreased expression of myocardial Cav-3 is an important reason for the increased sensitivity and vulnerability of MIRI in diabetes.In-depth study of the specific mechanism of Cav-3 in diabetic MIRI is expected to provide new targets and new strategies for the prevention and treatment of diabetic MIRI.

关 键 词：糖尿病 心肌缺血再灌注损伤 小窝蛋白3 

分 类 号：R587.2[医药卫生—内分泌] R542.2[医药卫生—内科学]