血管生成素样蛋白2在糖尿病血管并发症中的研究进展  

Research Progress of Angiopoietin-like Protein 2 in Diabetic Vascular Complication

作　　者：李晨菲 尹瑞梨 杨龙艳 赵冬[1] 王旭红[1] LI Chenfei;YIN Ruili;YANG Longyan;ZHAO Dong;WANG Xuhong(Center for Endocrinology Metabolism and Immune Diseases,Beijing Luhe Hospital,Capital Medical University,Beijing 101149,China)

机构地区：[1]首都医科大学附属北京潞河医院内分泌代谢与免疫性疾病中心,北京101149

出　　处：《医学综述》2023年第21期4715-4719,共5页Medical Recapitulate

摘　　要：糖尿病血管并发症是糖尿病患者住院率、死亡率增加的主要原因。糖尿病血管并发症主要包括冠心病、脑卒中和外周动脉疾病等大血管病变以及糖尿病视网膜病变、糖尿病肾脏疾病等微血管病变。慢性低度炎症是血管病变的病理基础,而血管生成素样蛋白2(ANGPTL2)可作为炎症反应通路中的递质在血管炎、动脉粥样硬化、肥胖相关的胰岛素抵抗、类风湿关节炎等炎症性疾病中发挥重要作用。近年来,ANGPTL2在糖尿病血管并发症疾病进展方面的作用受到广泛关注。未来对ANGPTL2进行深入研究或可为延缓糖尿病血管并发症提供新的治疗思路。Vascular complication of diabetes is a major cause of increased hospitalization and mortality in diabetic patients.Diabetic vascular complications mainly include macrovascular diseases such as coronary heart disease,stroke and peripheral artery disease,etc.and microvascular diseases such as diabetic retinopathy,and diabetic kidney disease etc.Chronic low-grade inflammation is the pathological basis of vascular lesions,and angiopoietin-like protein 2(ANGPTL2)can play an important role as a transmitter in the inflammatory response pathway in vasculitis,atherosclerosis,obesity-related insulin resistance,rheumatoid arthritis,and other inflammatory diseases.In recent years,ANGPTL2 has been widely concerned for its role in the disease progression of vascular complications in diabetes.Further research on ANGPTL2 in the future may provide new treatment ideas for delaying diabetic vascular complications.

关 键 词：糖尿病血管并发症 血管生成素样蛋白2 炎症反应 动脉粥样硬化 

分 类 号：R587.2[医药卫生—内分泌]