磁共振波谱技术在吸烟对大脑影响的研究进展  

Progress of Magnetic Resonance Spectroscopy in the Study of the Effects of Smoking on the Brain

作　　者：李任 常晓 张捷 张孝勇 LI Ren;CHANG Xiao;ZHANG Jie;ZHANG Xiaoyong(Institute of Science and Technology for Brain-Inspired Intelligence,Fudan University,Shanghai 200433,China)

机构地区：[1]复旦大学类脑智能科学与技术研究院,计算神经科学与类脑智能教育部重点实验室,上海200433

出　　处：《波谱学杂志》2023年第4期471-480,共10页Chinese Journal of Magnetic Resonance

基　　金：国家自然科学基金资助项目(82171903,92043301)。

摘　　要：吸烟是导致过早发病和死亡的主要风险因素之一.随着磁共振技术的不断进步,磁共振波谱已成为临床诊断的重要手段之一.与磁共振成像的其他模态一样,磁共振波谱具有无创性的优点,能够反映大脑的神经递质及代谢物的浓度变化情况.吸烟是一个全球性的健康问题,近些年已有一些研究利用磁共振波谱观察吸烟对大脑的影响.针对这一广泛关注的社会问题,本文对吸烟人群的磁共振波谱研究进展进行了综述,总结了烟草对大脑代谢的影响.本综述为深入研究烟草依赖的神经生物学机制提供了新的视角,从技术层面为早期诊断、治疗及预防吸烟对大脑的负面影响提供了支持.Smoking is one of the main risk factors for premature onset of illness and death.With the continuous advancement of magnetic resonance technology,magnetic resonance spectroscopy(MRS)has become a valuable diagnostic tool in clinical practice.Like other modalities of magnetic resonance imaging,MRS is non-invasive and can reflect changes in the concentration of neurotransmitters and metabolites in the brain.Smoking is a global health problem,and in recent years,some studies have applied MRS to observe the effects of smoking on the brain.This article reviews the progress in the use of MRS for studying the smoking population,summarizing the effects of tobacco on brain metabolism.This review provides a new perspective for in-depth research on the neurobiological mechanisms of tobacco dependence and technical support for the early diagnosis,treatment,and prevention of the negative effects of smoking on the brain.

关 键 词：磁共振波谱 代谢物 吸烟 大脑 

分 类 号：O482.53[理学—固体物理]