血清Zonulin和Metrnl水平与糖尿病肾病患者病情及预后的关系  

Relationship between serum Zonulin and Metrnl levels and condition and prognosis of diabetic nephropathy patients

作　　者：苗素芳 张维娜 张姣姣 MIAO Sufang;ZHANG Weina;ZHANG Jiaojiao(Department of Clinical Laboratory,The Second People's Hospital of Jincheng,Jincheng Shanxi 048000,China)

机构地区：[1]晋城市第二人民医院检验科,山西晋城048000

出　　处：《新疆医科大学学报》2023年第11期1513-1518,共6页Journal of Xinjiang Medical University

基　　金：山西省应用基础研究计划项目(201901D15291)。

摘　　要：目的分析血清连蛋白(Zonulin)、神经胶质细胞分化调节因子样因子(Metrnl)与糖尿病肾病(DN)患者病情严重程度及预后的关系。方法选取2018年1月至2020年1月晋城市第二人民医院收治的146例DN患者为研究对象(研究组),另选取同时期本院收治的146例2型糖尿病(T2DM)患者为对照组。将研究组患者根据Mogenson分期分为早期DN组和中晚期DN组。比较对照组与研究组、早期DN组与中晚期DN组患者血清Zonulin、Metrnl水平差异。血清Zonulin、Metrnl水平与DN患者病情严重程度的相关性采用Spearman相关性分析。根据对研究组患者的随访结果分为预后良好组和预后不良组,采用单因素和多因素分析影响DN患者预后不良的危险因素。结果研究组患者血清Zonulin水平高于对照组(P<0.05),Metrnl水平低于对照组(P<0.05)。中晚期DN组患者血清Zonulin水平高于早期DN组(P<0.05),Metrnl水平低于早期DN组(P<0.05)。Spearman相关性分析显示,血清Zonulin水平与糖尿病肾病患者病情严重程度呈正相关(r=0.486,P<0.05),血清Metrnl水平与糖尿病肾病患者病情严重程度呈负相关(r=-0.493,P<0.05)。预后不良组患者尿素氮(BUN)、Zonulin、血肌酐(Scr)、白细胞介素-6(IL-6)水平高于预后良好组(P<0.05),Metrnl、白蛋白(Alb)水平低于预后良好组(P<0.05)。Logistic回归分析显示血清Zonulin、Metrnl、Alb、IL-6水平异常均是影响DN患者预后不良的危险因素(P<0.05)。结论DN患者血清Zonulin水平随病情进展升高,Metrnl水平随病情进展降低,Zonulin水平异常升高、Metrnl水平异常降低均是影响DN患者预后不良的独立危险因素。Objective To analyze the relationship between serum(Zonulin),Meteorin-like(Metrnl)and the severity and prognosis of diabetic nephropathy(DN).Methods A total of 146 patients with DN admitted to the hospital from January 2018 to January 2020 were selected as study subjects(study group),and 146 patients with type 2 diabetes mellitus(T2DM)admitted thehospital during the same period were selected as control group.Patients in the study group were divided into early DN group and middle and late DN group according to Mogenson stage.The serum levels of Zonulin and Metrnl were compared between the control group and the research group,the early DN group and the middle and advanced DN group.The correlation between serum Zonulin and Metrnl levels and the severity of DN patients were analyzed by Spearman correlation analysis.At the same time,the patients in the study group were followed up and divided into good prognosis group and poor prognosis group according to the follow-up results.Univariate and multivariate analysis was used to analyze the risk factors affecting the poor prognosis of DN patients.Results The serum Zonulin level in the study group was higher than that in the control group(P<0.05),and the serum Metrnl level was lower than that in the control group(P<0.05).The serum Zonulin level in the middle and advanced DN group was higher than that in the early DN group(P<0.05),and the serum Metrnl level was lower than that in the early DN group(P<0.05).Spearman correlation analysis showed that serum Zonulin level was positively correlated with the severity of diabetic nephropathy patients(r=0.486,P<0.05),and serum Metrnl level was negatively correlated with the severity of diabetic nephropathy patients(r=-0.493,P<0.05).The levels of urea nitrogen(BUN),Zonulin,serum creatinine(Scr)and interleukin-6(IL-6)in poor prognosis group were higher than those in good prognosis group(P<0.05),and the levels of Metrnl and albumin(Alb)in poor prognosis group were lower than those in good prognosis group(P<0.05).Logistic regression ana

关 键 词：连蛋白(Zonulin) 神经胶质细胞分化调节因子样因子(Metrnl) 糖尿病肾病 预后 

分 类 号：R587[医药卫生—内分泌]