脂质谱异常对类风湿关节炎患者心血管健康的影响  

CROSS-SECTIONAL STUDY ON THE PREDICTIVE VALUE OF OXIDIZED LOW-DENSITY LIPOPROTEIN FOR CARDIOVASCULAR RISK IN PATIENTS WITH RHEUMATOID ARTHRITIS

作　　者：平春玲 铁宁[1] 李鸿斌[1] PING Chunling;TIE Ning;LI Hongbin(Department of Rheumatism,The Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China;Department of Rheumatism,Xilingol League Central Hospital,Xilinhot 026000,China)

机构地区：[1]内蒙古医科大学附属医院风湿免疫科,内蒙古呼和浩特010050 [2]锡林郭勒盟中心医院风湿免疫科,内蒙古锡林浩特026000

出　　处：《内蒙古医科大学学报》2023年第4期426-430,434,共6页Journal of Inner Mongolia Medical University

摘　　要：类风湿性关节炎是以滑膜细胞增殖和慢性炎症为临床表现的自身免疫性疾病,能侵蚀关节和引起其他器官损伤,导致心血管不良事件发生率较高。类风湿关节炎患者心血管疾病的高发病率和病死率不能完全用传统心血管风险因素解释。脂质悖论与类风湿关节炎患者的炎症负担有关,类风湿关节炎作为心血管疾病高风险因素之一与其血脂谱异常有关。本文就类风湿关节炎患者低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、总胆固醇水平的变化以及脂质过氧化对心血管健康的影响进行综述,为类风湿关节炎患者的健康治疗提供参考,在发病机制及临床上分析类风湿关节炎药物治疗后对其血脂及心血管系统等指标的变化,并通过评价及早发现高心血管疾病风险并制订合理治疗方案。Rheumatoid arthritis is an autoimmune disease characterized by synovial cell proliferation and chronic in-flammation that can erode joints and damage other organs.People at high risk of major cardiovascular events.The high inci-dence and mortality of cardiovascular disease in patients with rheumatoid arthritis cannot be explained solely by traditional cardiovascular risk factors.The lipid paradox is associated with inflammatory burden in patients with rheumatoid arthritis,a risk factor for cardiovascular disease.The effects of LDL cholesterol,density lipoprotein cholesterol,total cholesterol and lip-id peroxidation on cardiovascular health of RA patients were reviewed.Effect of drug therapy on blood lipid and cardiovascu-lar system in RA patients from pathogenesis and clinical perspective.Develop appropriate treatment plans for early detection of patients with rheumatoid arthritis who are at high risk of cardiovascular disease.

关 键 词：类风湿关节炎 心血管疾病 脂质谱 DMARDS 

分 类 号：R593.22[医药卫生—内科学]