瑞马唑仑联合纳布啡用于老年无痛胃镜检查效果观察  

Effect of Remimazolam Combined with Nalbuphine in Painless Gastroscopy in Elderly Patients

作　　者：张英[1] 蒯剑 徐向杨[1] 张春霞[1] 孙龙[1] ZHANG Ying;KUAI Jian;XU Xiangyang;ZHANG Chunxia;SUN Long(Qidong People's Hospital·Qidong Hospital Affiliated to Nantong University,Nantong,Jiangsu,China 226200)

机构地区：[1]江苏省启东市人民医院·南通大学附属启东医院,江苏南通226200

出　　处：《中国药业》2023年第23期111-114,共4页China Pharmaceuticals

基　　金：江苏省科学技术厅科技项目[BE2020427]。

摘　　要：目的探讨瑞马唑仑联合纳布啡用于老年无痛胃镜检查的效果。方法选取医院2021年12月至2022年12月收治的老年无痛胃镜检查患者88例,按随机数字表法分为对照组和观察组,各44例。对照组患者予瑞马唑仑联合舒芬太尼麻醉方案,观察组患者予瑞马唑仑联合纳布啡麻醉方案。结果观察组患者的麻醉诱导和苏醒时间均显著短于对照组(P<0.05);与麻醉前(T_(0))比较,两组患者麻醉后1 min(T_(1))、进镜时(T_(2))、检查结束时(T_(3))的平均动脉压(MAP)和心率(HR)均显著降低(P<0.05),但观察组T_(1)和T_(2)的MAP和HR均显著高于对照组(P<0.05);检查后,两组患者的肾上腺素、促肾上腺皮质激素、皮质醇水平均显著升高(P<0.05),但观察组均显著低于对照组(P<0.05);观察组的不良反应发生率为4.55%,显著低于对照组的18.18%(P<0.05)。结论瑞马唑仑联合纳布啡用于老年无痛胃镜检查,能缩短患者的麻醉诱导和苏醒时间,维持其生命体征稳定,减少应激反应对机体的影响,且安全性高。Objective To investigate the effect of remidazolam combined with nalbuphine in painless gastroscopy in elderly patients.Methods A total of 88 elderly patients underwent painless gastroscopy admitted to the hospital from December 2021 to December 2022 were selected and divided into the control group and the observation group according to the random number table method,with 44 cases in each group.The patients in the control group were given an anesthesia regimen of remidazolam and sufentanil,while the patients in the observation group were given an anesthesia regimen of remidazolam combined with nalbuphine.Results The anesthesia induction and recovery time in the observation group were significantly shorter than those in the control group(P<0.05);Compared with those before anesthesia(T_(0)),the mean arterial pressure(MAP)and heart rate(HR)in the two groups at 1 min after anesthesia(T_(1)),at the time of endoscopy(T_(2))and at the end of examination(T_(3))were significantly lower(P<0.05),but the MAP and HR in the observation group at T_(1) and T_(2) were significantly higher than those in the control group(P<0.05);the levels of adrenaline,adrenocorticotropic hormone,and cortisol in the two groups were significantly higher after examination(P<0.05),but those in the observation group were significantly lower than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was 4.55%,which was significantly lower than 18.18%in the control group(P<0.05).Conclusion The application of remidazolam combined with nalbuphine in elderly patients underwent painless gastroscopy can shorten the anesthesia induction time and recovery time,maintain the stability of vital signs,reduce the impact of stress reactions on the body,and have high safety.

关 键 词：瑞马唑仑 纳布啡 无痛胃镜 生命体征 应激反应 

分 类 号：R969.4[医药卫生—药理学] R971.2[医药卫生—药学]