3-氨基香豆素衍生的荧光探针  

Fluorescent Probes Derived from 3-Aminocoumarins

作　　者：张芮 刘学愚 胡云翔 帅林河 赵玉玲[3] ZHANG Rui;LIU Xue-yu;HU Yun-xiang;SHUAI Lin-he;ZHAO Yu-ling(Institute of Biochemistry and Molecular Biology,School of Life Sciences,Lanzhou University,Lanzhou 730000,China;Hangzhou Xinfu Science&Technology Limited Corporation,Hangzhou 311305,China;School of Chemistry and Chemical Engineering,Lanzhou Jiaotong University,Lanzhou 730070,China)

机构地区：[1]兰州大学生命科学学院生物化学与分子生物学研究所,甘肃兰州730000 [2]杭州鑫富科技有限公司,浙江杭州311305 [3]兰州交通大学化学化工学院,甘肃兰州730070

出　　处：《化学试剂》2023年第12期9-17,共9页Chemical Reagents

基　　金：国家自然科学基金资助项目(51563014)。

摘　　要：香豆素是常用的荧光生色团,在发展新型高效的荧光探针中有重要应用。3-氨基香豆素是一种α,β-脱氢氨基酸内酯,为其发展成为有多种生物活性与其他功能分子提供了独特的结构基础。迄今为止,以3-氨基香豆素为原料发展了一系列荧光探针分子,快速检测金属离子和生物分子。综述了以3-氨基香豆素为原料发展的一系列新的荧光探针,这些探针主要用于选择性地高效探测Hg^(2+)、Ag+、Cu^(2+)、Cu+、Pd^(2+)、Zn^(2+)和Cr^(2+)等多种金属离子、硫离子、半胱氨酸和β-巯基乙醇等生物硫醇、H_(2)O_(2)和活性蛋白质。Coumarin is a commonly used fluorescent chromophore,which has been applied in the development of novel and efficient fluorescent probes.3-Aminocoumarin is anα,β-dehydroamino acid lactone,whose unique structure provides a strong basis for this compound to be developed into versatile molecules with biological activities and other diverse functions.A number of fluorescent probes have been developed using 3-aminocoumarins for the rapid determination of metal ions and biomolecules.This article reviews the literatures involving these novel fluorescent probes developed from 3-aminocoumarin applied in the selective detection of metal ions(Hg^(2+),Ag+,Cu^(2+),Cu+,Pd^(2+),Zn^(2+)and Cr^(2+)),sulfur ions,Cys,β-mercaptoethanol and so on,H_(2)O_(2),and active proteins.

关 键 词：荧光探针 3-氨基香豆素 金属离子 生物硫醇 活性蛋白质 

分 类 号：O65[理学—分析化学]