基于蒲地蓝药物组成碳点的制备及表征  

Preparation and Characterization of Carbon Dots Based on Pudilan

作　　者：王宇 吴晨涛 阙子淼 于诗源 喻春皓 WANG Yu;WU Chentao;QUE Zimiao;YU Shiyuan;YU Chunhao(College of Chemical Engineering,Huaiyin Institute of Technology,Huai’an Jiangsu 223003,China)

机构地区：[1]淮阴工学院化学工程学院,江苏淮安223003

出　　处：《淮阴工学院学报》2023年第5期27-34,共8页Journal of Huaiyin Institute of Technology

基　　金：江苏省高等学校自然科学研究重大项目(18KJA360001);江苏省产学研前瞻性联合研究项目(BY2016061-22)。

摘　　要：以中成药蒲地蓝制剂的药物组成苦地丁、板蓝根、黄芩、蒲公英为碳源,采用一步水热法组合制备共15种碳点(car-bon dots,CDs)。用紫外、荧光等对CDs进行光学性能表征,选取荧光强度为指标,将每类组合的最佳搭配进行激发和发射光谱的比较,后续进行红外官能团分析及XRD形貌表征。结果表明:药材种类、组合方式对CDs的量子产率有明显的影响,最大UV吸收峰位于283 nm左右;板蓝根CD的量子产率最高,达到17.80%;单味中药CDs最佳激发和发射波长分别为325,400nm。组合后CDs最佳激发波长偏移到300nm且发射波长小于400nm。红外、XRD表征显示制备的CDs属于无定形碳,表面富含羟基、氨基等官能团,与其他碳源CDs基本一致。通过单味中药与组合中药CDs光学性能及微观结构的表征,经组合后的CDs性质可能发生变化,为后续将中药作为碳源进行深入研究提供了基础。A total of 15 kinds of carbon dots(CDs)were prepared by one-step hydrothermal method using Kudadium,Radix isatidis,Scutellaria scutellaria and dandelion as carbon sources.The optical prop⁃erties of CDs were characterized by UV and fluorescence,and the fluorescence intensity was selected as the index.The excitation and emission spectra were compared between the best combinations of each type of combination,followed by infrared functional group analysis and XRD morphology character⁃ization.The results showed that the quantum yield of CDs was significantly affected by the species and combination of medicinal materials,and the maximum UV absorption peak was about 283 nm.The quantum yield of Radix isatidis CD was the highest,reaching 17.80%.The optimal excitation and emis⁃sion wavelengths of CDs for single TCM were 325 nm and 400 nm,respectively.After combination,the optimal excitation wavelength of CDs is shifted to 300 nm and the emission wavelength is less than 400 nm.Infrared and XRD characterization showed that the prepared CDs belonged to amorphous car⁃bon,and the surface was rich in hydroxyl,amino and other functional groups,basically consistent with other carbon source CDs.Through the characterization of the optical properties and microstructure of CDs of single and combined TCM,the properties of CDs may change after combination,which provides the basic work for further research on the use of TCM as carbon source.

关 键 词：蒲地蓝 碳点 荧光 量子产率 

分 类 号：R284[医药卫生—中药学]